E3 ubiquitin ligase Cbl-b in innate and adaptive immunity

Q. Liu, Wallace Langdon, J. Zhang

Research output: Contribution to journalReview article

22 Citations (Scopus)

Abstract

Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b), a RING finger E3 ubiquitin-protein ligase, has been demonstrated to play a crucial role in establishing the threshold for T-cell activation and controlling peripheral T-cell tolerance via multiple mechanisms. Accumulating evidence suggests that Cbl-b also regulates innate immune responses and plays an important role in host defense to pathogens. Understanding the signaling pathways regulated by Cbl-b in innate and adaptive immune cells is therefore essential for efficient manipulation of Cbl-b in emerging immunotherapies for human disorders such as autoimmune diseases, allergic inflammation, infections, and cancer. In this article, we review the latest developments in the molecular structural basis of Cbl-b function, the regulation of Cbl-b expression, the signaling mechanisms of Cbl-b in immune cells, as well as the biological function of Cbl-b in physiological and pathological immune responses in animal models and human diseases. © 2014 Landes Bioscience.
Original languageEnglish
Pages (from-to)1875-1884
JournalCell Cycle
Volume13
Issue number12
DOIs
Publication statusPublished - 2014

Fingerprint

Ubiquitin-Protein Ligases
Proto-Oncogenes
Adaptive Immunity
Innate Immunity
Lymphoma
T-Lymphocytes
Animal Disease Models
Immunotherapy
Autoimmune Diseases
Inflammation
Infection

Cite this

Liu, Q. ; Langdon, Wallace ; Zhang, J. / E3 ubiquitin ligase Cbl-b in innate and adaptive immunity. In: Cell Cycle. 2014 ; Vol. 13, No. 12. pp. 1875-1884.
@article{52f20d7536da420b9f1822540c7c075a,
title = "E3 ubiquitin ligase Cbl-b in innate and adaptive immunity",
abstract = "Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b), a RING finger E3 ubiquitin-protein ligase, has been demonstrated to play a crucial role in establishing the threshold for T-cell activation and controlling peripheral T-cell tolerance via multiple mechanisms. Accumulating evidence suggests that Cbl-b also regulates innate immune responses and plays an important role in host defense to pathogens. Understanding the signaling pathways regulated by Cbl-b in innate and adaptive immune cells is therefore essential for efficient manipulation of Cbl-b in emerging immunotherapies for human disorders such as autoimmune diseases, allergic inflammation, infections, and cancer. In this article, we review the latest developments in the molecular structural basis of Cbl-b function, the regulation of Cbl-b expression, the signaling mechanisms of Cbl-b in immune cells, as well as the biological function of Cbl-b in physiological and pathological immune responses in animal models and human diseases. {\circledC} 2014 Landes Bioscience.",
author = "Q. Liu and Wallace Langdon and J. Zhang",
year = "2014",
doi = "10.4161/cc.29213",
language = "English",
volume = "13",
pages = "1875--1884",
journal = "Cell Cycle",
issn = "1538-4101",
publisher = "Landes Bioscience",
number = "12",

}

E3 ubiquitin ligase Cbl-b in innate and adaptive immunity. / Liu, Q.; Langdon, Wallace; Zhang, J.

In: Cell Cycle, Vol. 13, No. 12, 2014, p. 1875-1884.

Research output: Contribution to journalReview article

TY - JOUR

T1 - E3 ubiquitin ligase Cbl-b in innate and adaptive immunity

AU - Liu, Q.

AU - Langdon, Wallace

AU - Zhang, J.

PY - 2014

Y1 - 2014

N2 - Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b), a RING finger E3 ubiquitin-protein ligase, has been demonstrated to play a crucial role in establishing the threshold for T-cell activation and controlling peripheral T-cell tolerance via multiple mechanisms. Accumulating evidence suggests that Cbl-b also regulates innate immune responses and plays an important role in host defense to pathogens. Understanding the signaling pathways regulated by Cbl-b in innate and adaptive immune cells is therefore essential for efficient manipulation of Cbl-b in emerging immunotherapies for human disorders such as autoimmune diseases, allergic inflammation, infections, and cancer. In this article, we review the latest developments in the molecular structural basis of Cbl-b function, the regulation of Cbl-b expression, the signaling mechanisms of Cbl-b in immune cells, as well as the biological function of Cbl-b in physiological and pathological immune responses in animal models and human diseases. © 2014 Landes Bioscience.

AB - Casitas B-lineage lymphoma proto-oncogene-b (Cbl-b), a RING finger E3 ubiquitin-protein ligase, has been demonstrated to play a crucial role in establishing the threshold for T-cell activation and controlling peripheral T-cell tolerance via multiple mechanisms. Accumulating evidence suggests that Cbl-b also regulates innate immune responses and plays an important role in host defense to pathogens. Understanding the signaling pathways regulated by Cbl-b in innate and adaptive immune cells is therefore essential for efficient manipulation of Cbl-b in emerging immunotherapies for human disorders such as autoimmune diseases, allergic inflammation, infections, and cancer. In this article, we review the latest developments in the molecular structural basis of Cbl-b function, the regulation of Cbl-b expression, the signaling mechanisms of Cbl-b in immune cells, as well as the biological function of Cbl-b in physiological and pathological immune responses in animal models and human diseases. © 2014 Landes Bioscience.

U2 - 10.4161/cc.29213

DO - 10.4161/cc.29213

M3 - Review article

VL - 13

SP - 1875

EP - 1884

JO - Cell Cycle

JF - Cell Cycle

SN - 1538-4101

IS - 12

ER -