Dysregulation of CD28 and CTLA-4 expression by CD4 T cells from previously immunodeficient HIV-infected patients with sustained virological responses to highly active antiretroviral therapy

Shelley Stone, Patricia Price, Martyn French

Research output: Contribution to journalArticlepeer-review

25 Citations (Scopus)

Abstract

Objectives Current guidelines recommend commencing highly active antiretroviral therapy (HAART) in HIV-infected patients when CD4 T-cell counts reach 350 cells/μL. However, late-presenting HIV-infected patients with CD4 T-cell counts4 years on HAART and >6 months of complete viral suppression (1% of CD4 lymphocytes expressing perforin [11 of 25 (44%) vs. one of 18 (5.5%)]. The percentage of CD8 lymphocytes expressing perforin did not differ between HIV-infected patients and controls. Amongst HIV-infected patients, the percentage of perforin-expressing CD8 lymphocytes correlated inversely with nadir but not current CD4 T-cell count. Conclusions Expression of CD28, CTLA-4 and perforin by CD4 lymphocytes remain dysregulated in HIV-infected patients with previous severe immunodeficiency, despite increased CD4 T-cell counts and control of HIV viraemia by HAART.
Original languageEnglish
Pages (from-to)278-283
JournalHIV Medicine
Volume6
Issue number4
DOIs
Publication statusPublished - 2005

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