Dysregulated CD40 and CD40 ligand expression in anti–N-methyl-D-aspartate receptor encephalitis

Xiaoyu Ma; Chen Chen; Ling Fang; Xiaonan Zhong; Yanyu Chang; Rui Li; Yuge Wang; Xueqiang Hu; Wei Qiu; Yaqing Shu

doi:10.1016/j.jneuroim.2021.577762

Dysregulated CD40 and CD40 ligand expression in anti–N-methyl-D-aspartate receptor encephalitis

Xiaoyu Ma, Chen Chen, Ling Fang, Xiaonan Zhong, Yanyu Chang, Rui Li, Yuge Wang, Xueqiang Hu, Wei Qiu, Yaqing Shu

Research output: Contribution to journal › Article › peer-review

2 Citations (Scopus)

Abstract

Anti–N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.

Original language	English
Article number	577762
Journal	Journal of Neuroimmunology
Volume	362
DOIs	https://doi.org/10.1016/j.jneuroim.2021.577762
Publication status	Published - 15 Jan 2022
Externally published	Yes

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10.1016/j.jneuroim.2021.577762

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title = "Dysregulated CD40 and CD40 ligand expression in anti–N-methyl-D-aspartate receptor encephalitis",

abstract = "Anti–N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.",

keywords = "Anti–N-methyl-D-aspartate receptor encephalitis, CD40, CD40 ligand, Pathway, Serum",

author = "Xiaoyu Ma and Chen Chen and Ling Fang and Xiaonan Zhong and Yanyu Chang and Rui Li and Yuge Wang and Xueqiang Hu and Wei Qiu and Yaqing Shu",

note = "Funding Information: This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2021A1515010393), the National Natural Science Foundation of China (No. 82071343), and the National Natural Science Foundation of China Youth Science Foundation (No. 81701188). Publisher Copyright: {\textcopyright} 2021",

year = "2022",

month = jan,

day = "15",

doi = "10.1016/j.jneuroim.2021.577762",

language = "English",

volume = "362",

journal = "Journal of Neuroimmunology",

issn = "0165-5728",

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TY - JOUR

T1 - Dysregulated CD40 and CD40 ligand expression in anti–N-methyl-D-aspartate receptor encephalitis

AU - Ma, Xiaoyu

AU - Chen, Chen

AU - Fang, Ling

AU - Zhong, Xiaonan

AU - Chang, Yanyu

AU - Li, Rui

AU - Wang, Yuge

AU - Hu, Xueqiang

AU - Qiu, Wei

AU - Shu, Yaqing

N1 - Funding Information: This study was supported by the Guangdong Basic and Applied Basic Research Foundation (2021A1515010393), the National Natural Science Foundation of China (No. 82071343), and the National Natural Science Foundation of China Youth Science Foundation (No. 81701188). Publisher Copyright: © 2021

PY - 2022/1/15

Y1 - 2022/1/15

N2 - Anti–N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.

AB - Anti–N-methyl-D-aspartate receptor encephalitis (anti-NMDARE) is a B cell- and antibody-mediated autoimmune disease which may be regulated by CD40/CD40L signaling pathway. we enrolled anti-NMDARE patients and measured the serum CD40 and CD40L concentrations. The serum concentration of CD40 was decreased, while CD40L was increased in anti-NMDARE patients compared with that of healthy controls. The concentrations of CD40 and CD40L were both elevated in the acute stage of anti-NMDARE and were reduced during remission. Serum CD40L levels were positively correlated with serum CD40 levels. These results revealed that the CD40/CD40L signaling pathway might contribute to the pathogenesis of anti-NMDARE.

KW - Anti–N-methyl-D-aspartate receptor encephalitis

KW - CD40

KW - CD40 ligand

KW - Pathway

KW - Serum

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DO - 10.1016/j.jneuroim.2021.577762

M3 - Article

C2 - 34839148

AN - SCOPUS:85119937055

SN - 0165-5728

VL - 362

JO - Journal of Neuroimmunology

JF - Journal of Neuroimmunology

M1 - 577762

ER -

Dysregulated CD40 and CD40 ligand expression in anti–N-methyl-D-aspartate receptor encephalitis

Abstract

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