Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

L. Cui; D. Liu; W. Shi; J. Pan; X. Qi; X. Li; X. Guo; M. Zhou; W. Li; J. Li; Joel D. Haywood; H. Xiao; X. Yu; X. Pu; Y. Wu; H. Yu; K. Zhao; Y. Zhu; B. Wu; T. Jin; Z. Shi; F. Tang; F. Zhu; Q. Sun; L. Wu; R. Yang; J. Yan; F. Lei; B. Zhu; W. Liu; J. Ma; H. Wang; G.F. F. Gao

doi:10.1038/ncomms4142

Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

L. Cui, D. Liu, W. Shi, J. Pan, X. Qi, X. Li, X. Guo, M. Zhou, W. Li, J. Li, Joel D. Haywood, H. Xiao, X. Yu, X. Pu, Y. Wu, H. Yu, K. Zhao, Y. Zhu, B. Wu, T. JinZ. Shi, F. Tang, F. Zhu, Q. Sun, L. Wu, R. Yang, J. Yan, F. Lei, B. Zhu, W. Liu, J. Ma, H. Wang, G.F. F. Gao

Research output: Contribution to journal › Article › peer-review

144 Citations (Web of Science)

Abstract

Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter- and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment. © 2014 Macmillan Publishers Limited. All rights reserved.

Original language	English
Article number	3142
Number of pages	9
Journal	Nature Communications
Volume	5
DOIs	https://doi.org/10.1038/ncomms4142
Publication status	Published - 2014
Externally published	Yes

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@article{0ca97867d2734763bfe8e3e578beed7b,

title = "Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus",

abstract = "Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter- and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment. {\textcopyright} 2014 Macmillan Publishers Limited. All rights reserved.",

author = "L. Cui and D. Liu and W. Shi and J. Pan and X. Qi and X. Li and X. Guo and M. Zhou and W. Li and J. Li and Haywood, {Joel D.} and H. Xiao and X. Yu and X. Pu and Y. Wu and H. Yu and K. Zhao and Y. Zhu and B. Wu and T. Jin and Z. Shi and F. Tang and F. Zhu and Q. Sun and L. Wu and R. Yang and J. Yan and F. Lei and B. Zhu and W. Liu and J. Ma and H. Wang and Gao, {G.F. F.}",

year = "2014",

doi = "10.1038/ncomms4142",

language = "English",

volume = "5",

journal = "Nature Communications",

issn = "2041-1723",

publisher = "Nature Publishing Group - Macmillan Publishers",

}

Cui, L, Liu, D, Shi, W, Pan, J, Qi, X, Li, X, Guo, X, Zhou, M, Li, W, Li, J, Haywood, JD, Xiao, H, Yu, X, Pu, X, Wu, Y, Yu, H, Zhao, K, Zhu, Y, Wu, B, Jin, T, Shi, Z, Tang, F, Zhu, F, Sun, Q, Wu, L, Yang, R, Yan, J, Lei, F, Zhu, B, Liu, W, Ma, J, Wang, H & Gao, GFF 2014, 'Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus', Nature Communications, vol. 5, 3142. https://doi.org/10.1038/ncomms4142

TY - JOUR

T1 - Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

AU - Cui, L.

AU - Liu, D.

AU - Shi, W.

AU - Pan, J.

AU - Qi, X.

AU - Li, X.

AU - Guo, X.

AU - Zhou, M.

AU - Li, W.

AU - Li, J.

AU - Haywood, Joel D.

AU - Xiao, H.

AU - Yu, X.

AU - Pu, X.

AU - Wu, Y.

AU - Yu, H.

AU - Zhao, K.

AU - Zhu, Y.

AU - Wu, B.

AU - Jin, T.

AU - Shi, Z.

AU - Tang, F.

AU - Zhu, F.

AU - Sun, Q.

AU - Wu, L.

AU - Yang, R.

AU - Yan, J.

AU - Lei, F.

AU - Zhu, B.

AU - Liu, W.

AU - Ma, J.

AU - Wang, H.

AU - Gao, G.F. F.

PY - 2014

Y1 - 2014

N2 - Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter- and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment. © 2014 Macmillan Publishers Limited. All rights reserved.

AB - Influenza A (H7N9) virus has been causing human infections in China since February 2013, raising serious concerns of potential pandemics. Previous studies demonstrate that human infection is directly linked to live animal markets, and that the internal genes of the virus are derived from H9N2 viruses circulating in the Yangtze River Delta area in Eastern China. Here following analysis of 109 viruses, we show a much higher genetic heterogeneity of the H7N9 viruses than previously reported, with a total of 27 newly designated genotypes. Phylogenetic and genealogical inferences reveal that genotypes G0 and G2.6 dominantly co-circulate within poultry, with most human isolates belonging to the genotype G0. G0 viruses are also responsible for the inter- and intra-province transmissions, leading to the genesis of novel genotypes. These observations suggest the province-specific H9N2 virus gene pools increase the genetic diversity of H7N9 via dynamic reassortments and also imply that G0 has not gained overwhelming fitness and the virus continues to undergo reassortment. © 2014 Macmillan Publishers Limited. All rights reserved.

U2 - 10.1038/ncomms4142

DO - 10.1038/ncomms4142

M3 - Article

SN - 2041-1723

VL - 5

JO - Nature Communications

JF - Nature Communications

M1 - 3142

ER -

Dynamic reassortments and genetic heterogeneity of the human-infecting influenza A (H7N9) virus

Abstract

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