@article{0a6c70fa5fac44c6bb6699b33033752c,
title = "Dynamic molecular changes during the first week of human life follow a robust developmental trajectory",
abstract = "Systems biology can unravel complex biology but has not been extensively applied to human newborns, a group highly vulnerable to a wide range of diseases. We optimized methods to extract transcriptomic, proteomic, metabolomic, cytokine/chemokine, and single cell immune phenotyping data from <1 ml of blood, a volume readily obtained from newborns. Indexing to baseline and applying innovative integrative computational methods reveals dramatic changes along a remarkably stable developmental trajectory over the first week of life. This is most evident in changes of interferon and complement pathways, as well as neutrophil-associated signaling. Validated across two independent cohorts of newborns from West Africa and Australasia, a robust and common trajectory emerges, suggesting a purposeful rather than random developmental path. Systems biology and innovative data integration can provide fresh insights into the molecular ontogeny of the first week of life, a dynamic developmental phase that is key for health and disease.",
author = "{The EPIC Consortium} and Lee, {Amy H.} and Shannon, {Casey P.} and Nelly Amenyogbe and Bennike, {Tue B.} and Joann Diray-Arce and Idoko, {Olubukola T.} and Gill, {Erin E.} and Rym Ben-Othman and Pomat, {William S.} and {van Haren}, {Simon D.} and Cao, {Kim Anh L{\^e}} and Momoudou Cox and Alansana Darboe and Reza Falsafi and Davide Ferrari and Harbeson, {Daniel J.} and Daniel He and Cai Bing and Hinshaw, {Samuel J.} and Jorjoh Ndure and Jainaba Njie-Jobe and Pettengill, {Matthew A.} and Richmond, {Peter C.} and Rebecca Ford and Gerard Saleu and Geraldine Masiria and Matlam, {John Paul} and Wendy Kirarock and Elishia Roberts and Mehrnoush Malek and Guzm{\'a}n Sanchez-Schmitz and Amrit Singh and Asimenia Angelidou and Smolen, {Kinga K.} and Diana Vo and Ken Kraft and Kerry McEnaney and Sofia Vignolo and Arnaud Marchant and Brinkman, {Ryan R.} and Al Ozonoff and Hancock, {Robert E.W.} and {van den Biggelaar}, {Anita H.J.} and Hanno Steen and Tebbutt, {Scott J.} and Beate Kampmann and Ofer Levy and Kollmann, {Tobias R.}",
year = "2019",
month = dec,
day = "1",
doi = "10.1038/s41467-019-08794-x",
language = "English",
volume = "10",
journal = "Nature Communications",
issn = "2041-1723",
publisher = "Nature Publishing Group - Macmillan Publishers",
number = "1",
}
