Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation

Amy Prosser, Wen Hua Huang, Liu Liu, Sarah Dart, Monalyssa Watson, Bastiaan de Boer, Philip Kendrew, Andrew Lucas, Irma Larma-Cornwall, Silvana Gaudieri, Gary P. Jeffrey, Luc Delriviere, Axel Kallies, Michaela Lucas

Research output: Contribution to journalArticlepeer-review

Abstract

The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity and repair. Their vital functions in normal physiology suggest an important role in solid organ transplantation; however, their detailed examination in this context has not been performed. Here, we report the fate of multiple lymphocyte subsets, including T, B, and innate lymphoid cells, after murine liver and heart transplantation. In major histocompatibility complex (MHC)-matched transplantation, donor lymphocytes are retained in liver grafts and peripheral lymphoid organs of heart and liver transplant recipients. In MHC-mismatched transplantation, increased infiltration of the graft by recipient cells and depletion of donor lymphocytes occur, which can be prevented by removal of recipient T and B cells. Recipient lymphocytes fail to recreate the native organs’ phenotypically diverse tissue-resident lymphocyte composition, even in MHC-matched models. These post-transplant changes may leave grafts vulnerable to infection and impair long-term graft function.

Original languageEnglish
Article number109141
JournalCell Reports
Volume35
Issue number7
DOIs
Publication statusPublished - 18 May 2021

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