TY - JOUR
T1 - Dynamic changes to tissue-resident immunity after MHC-matched and MHC-mismatched solid organ transplantation
AU - Prosser, Amy
AU - Huang, Wen Hua
AU - Liu, Liu
AU - Dart, Sarah
AU - Watson, Monalyssa
AU - de Boer, Bastiaan
AU - Kendrew, Philip
AU - Lucas, Andrew
AU - Larma-Cornwall, Irma
AU - Gaudieri, Silvana
AU - Jeffrey, Gary P.
AU - Delriviere, Luc
AU - Kallies, Axel
AU - Lucas, Michaela
PY - 2021/5/18
Y1 - 2021/5/18
N2 - The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity and repair. Their vital functions in normal physiology suggest an important role in solid organ transplantation; however, their detailed examination in this context has not been performed. Here, we report the fate of multiple lymphocyte subsets, including T, B, and innate lymphoid cells, after murine liver and heart transplantation. In major histocompatibility complex (MHC)-matched transplantation, donor lymphocytes are retained in liver grafts and peripheral lymphoid organs of heart and liver transplant recipients. In MHC-mismatched transplantation, increased infiltration of the graft by recipient cells and depletion of donor lymphocytes occur, which can be prevented by removal of recipient T and B cells. Recipient lymphocytes fail to recreate the native organs’ phenotypically diverse tissue-resident lymphocyte composition, even in MHC-matched models. These post-transplant changes may leave grafts vulnerable to infection and impair long-term graft function.
AB - The heterogeneous pool of tissue-resident lymphocytes in solid organs mediates infection responses and supports tissue integrity and repair. Their vital functions in normal physiology suggest an important role in solid organ transplantation; however, their detailed examination in this context has not been performed. Here, we report the fate of multiple lymphocyte subsets, including T, B, and innate lymphoid cells, after murine liver and heart transplantation. In major histocompatibility complex (MHC)-matched transplantation, donor lymphocytes are retained in liver grafts and peripheral lymphoid organs of heart and liver transplant recipients. In MHC-mismatched transplantation, increased infiltration of the graft by recipient cells and depletion of donor lymphocytes occur, which can be prevented by removal of recipient T and B cells. Recipient lymphocytes fail to recreate the native organs’ phenotypically diverse tissue-resident lymphocyte composition, even in MHC-matched models. These post-transplant changes may leave grafts vulnerable to infection and impair long-term graft function.
KW - heart transplantation
KW - innate lymphoid cell
KW - liver transplantation
KW - tissue-resident lymphocyte
KW - unconventional T cell
UR - http://www.scopus.com/inward/record.url?scp=85105968541&partnerID=8YFLogxK
U2 - 10.1016/j.celrep.2021.109141
DO - 10.1016/j.celrep.2021.109141
M3 - Article
C2 - 34010637
AN - SCOPUS:85105968541
VL - 35
JO - Cell Reports
JF - Cell Reports
SN - 2211-1247
IS - 7
M1 - 109141
ER -