Duration of untreated bipolar disorder: A multicenter study

Ling Zhang, Xin Yu, Yi Ru Fang, Gabor S. Ungvari, Chee H. Ng, Helen F K Chiu, Hui Chun Li, Hai Chen Yang, Qing Rong Tan, Xiu Feng Xu, Gang Wang, Yu-Tao Xiang

    Research output: Contribution to journalArticlepeer-review

    17 Citations (Web of Science)


    Little is known about the demographic and clinical differences between short and long duration of untreated bipolar disorder (DUB) in Chinese patients. This study examined the demographic and clinical features of short (≤2 years) and long DUB (>2 years) in China. A consecutively recruited sample of 555 patients with bipolar disorder (BD) was examined in 7 psychiatric hospitals and general hospital psychiatric units across China. Patients' demographic and clinical characteristics were collected using a standardized protocol and data collection procedure. The mean DUB was 3.2 ± 6.0 years; long DUB accounted for 31.0% of the sample. Multivariate analyses revealed that longer duration of illness, diagnosis of BD type II, and earlier misdiagnosis of BD for major depressive disorder or schizophrenia were independently associated with long DUB. The mean DUB in Chinese BD patients was shorter than the reported figures from Western countries. The long-term impact of DUB on the outcome of BD is warranted.

    Original languageEnglish
    Article number44811
    JournalScientific Reports
    Publication statusPublished - 22 Mar 2017


    Dive into the research topics of 'Duration of untreated bipolar disorder: A multicenter study'. Together they form a unique fingerprint.

    Cite this