TY - JOUR
T1 - Duration of Antimicrobial Prophylaxis in Vascular Surgery
AU - Hall, John
AU - Christiansen, K.J.
AU - Goodman, M.
AU - Lawrence-Brown, M.
AU - Prendergast, F.J.
AU - Rosenberg, P.
AU - Mills, B.
AU - Hall, Jane
PY - 1998
Y1 - 1998
N2 - BACKGROUND: This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).METHODS: Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92).CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.
AB - BACKGROUND: This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).METHODS: Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92).CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.
U2 - 10.1016/S0002-9610(97)00270-5
DO - 10.1016/S0002-9610(97)00270-5
M3 - Article
VL - 175
SP - 87
EP - 90
JO - American Journal of Surgery
JF - American Journal of Surgery
SN - 0002-9610
ER -