Duration of Antimicrobial Prophylaxis in Vascular Surgery

John Hall; K.J. Christiansen; M. Goodman; M. Lawrence-Brown; F.J. Prendergast; P. Rosenberg; B. Mills; Jane Hall

doi:10.1016/S0002-9610(97)00270-5

Duration of Antimicrobial Prophylaxis in Vascular Surgery

John Hall, K.J. Christiansen, M. Goodman, M. Lawrence-Brown, F.J. Prendergast, P. Rosenberg, B. Mills, Jane Hall

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Abstract

BACKGROUND: This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).METHODS: Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92).CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.

Original language	English
Pages (from-to)	87-90
Journal	American Journal of Surgery
Volume	175
DOIs	https://doi.org/10.1016/S0002-9610(97)00270-5
Publication status	Published - 1998

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@article{3e52ecb076f547149c3c8b7cfb3e6157,

title = "Duration of Antimicrobial Prophylaxis in Vascular Surgery",

abstract = "BACKGROUND: This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).METHODS: Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92).CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.",

author = "John Hall and K.J. Christiansen and M. Goodman and M. Lawrence-Brown and F.J. Prendergast and P. Rosenberg and B. Mills and Jane Hall",

year = "1998",

doi = "10.1016/S0002-9610(97)00270-5",

language = "English",

volume = "175",

pages = "87--90",

journal = "American Journal of Surgery",

issn = "0002-9610",

publisher = "Elsevier",

}

TY - JOUR

T1 - Duration of Antimicrobial Prophylaxis in Vascular Surgery

AU - Hall, John

AU - Christiansen, K.J.

AU - Goodman, M.

AU - Lawrence-Brown, M.

AU - Prendergast, F.J.

AU - Rosenberg, P.

AU - Mills, B.

AU - Hall, Jane

PY - 1998

Y1 - 1998

N2 - BACKGROUND: This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).METHODS: Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92).CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.

AB - BACKGROUND: This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).METHODS: Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92).CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.

U2 - 10.1016/S0002-9610(97)00270-5

DO - 10.1016/S0002-9610(97)00270-5

M3 - Article

VL - 175

SP - 87

EP - 90

JO - American Journal of Surgery

JF - American Journal of Surgery

SN - 0002-9610

ER -