Duration of Antimicrobial Prophylaxis in Vascular Surgery

John Hall, K.J. Christiansen, M. Goodman, M. Lawrence-Brown, F.J. Prendergast, P. Rosenberg, B. Mills, Jane Hall

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    50 Citations (Scopus)


    BACKGROUND: This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single-dose or a multiple-dose regimen (until the lines/drain tubes were removed, but not for more than 5 days).METHODS: Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20).RESULTS: The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence Interval = -1.02 to 3.92).CONCLUSIONS: A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. (C) 1998 by Excerpta Medica, Inc.
    Original languageEnglish
    Pages (from-to)87-90
    JournalAmerican Journal of Surgery
    Publication statusPublished - 1998


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