Drug release characteristics of phase separation pHEMA sponge materials

X. Lou, S. Munro, Song Wang

    Research output: Contribution to journalArticle

    65 Citations (Scopus)

    Abstract

    A number of phase separation pHEMA sponge hydrogels have been prepared based on variations in monomer contents, concentration of cross-linking agent, solvent mixture and temperature of polymerization. The loading levels and release profiles of the anti-inflammatory drug prednisolone were examined for each of the pHEMA sponge materials. An effective diffusion coefficient determined by an optimization approach based on the experimental data was used to measure their release characteristics. The effect of morphological variations, revealed by the environmental scanning electron microscopy, and polymer/solvent volume fractions on these properties were discussed. (C) 2004 Elsevier Ltd. All rights reserved.
    Original languageEnglish
    Pages (from-to)5071-5080
    JournalBiomaterials
    Volume25
    Issue number20
    DOIs
    Publication statusPublished - 2004

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