TY - JOUR
T1 - Drug reaction with eosinophilia and systemic symptoms
T2 - A complex interplay between drug, T cells, and herpesviridae
AU - Ganeshanandan, Luckshman
AU - Lucas, Michaela
PY - 2021/2/1
Y1 - 2021/2/1
N2 - Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug induced hypersensitivity (DiHS) syndrome is a severe delayed hypersensitivity reaction with potentially fatal consequences. Whilst recognised as T cell-mediated, our understanding of the immunopathogenesis of this syndrome remains incomplete. Here, we discuss models of DRESS, including the role of human leukocyte antigen (HLA) and how observations derived from new molecular techniques adopted in key studies have informed our mechanism-based understanding of the central role of Herpesviridae reactivation and heterologous immunity in these disorders.
AB - Drug reaction with eosinophilia and systemic symptoms (DRESS) syndrome, also known as drug induced hypersensitivity (DiHS) syndrome is a severe delayed hypersensitivity reaction with potentially fatal consequences. Whilst recognised as T cell-mediated, our understanding of the immunopathogenesis of this syndrome remains incomplete. Here, we discuss models of DRESS, including the role of human leukocyte antigen (HLA) and how observations derived from new molecular techniques adopted in key studies have informed our mechanism-based understanding of the central role of Herpesviridae reactivation and heterologous immunity in these disorders.
KW - Drug induced hypersensitivity syndrome
KW - Eosinophilia
KW - Herpesviridae
KW - Reaction
UR - http://www.scopus.com/inward/record.url?scp=85099914630&partnerID=8YFLogxK
U2 - 10.3390/ijms22031127
DO - 10.3390/ijms22031127
M3 - Review article
C2 - 33498771
AN - SCOPUS:85099914630
SN - 1661-6596
VL - 22
SP - 1
EP - 11
JO - International Journal of Molecular Sciences
JF - International Journal of Molecular Sciences
IS - 3
M1 - 1127
ER -