Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases

Research output: Contribution to conferenceAbstract

Abstract

Drug therapy to stabilize insulin resistance and various chronic diseases that reverse cell senescence and apoptosis has been implemented in various global populations. The need to optimize drug therapy and improve therapeutic outcomes has become of major concern with relevance to alarming reports of drug-drug interactions or drug-disease interactions with relevance to the global chronic disease epidemic. In diseases of the heart, brain and liver cell senescence is now connected to mitochondrial apoptosis with nutrition of major importance in the maintenance of mitochondrial biogenesis and the prevention of NAFLD and obesity. The search for specific genes that maintain mitochondria biogenesis has identified the anti-aging gene Sirtuin 1 (Sirt 1) as the gene involved in mitochondrial biogenesis. Sirt 1 is a NAD+ dependent class III histone deacetylase activity involved in the regulation of metabolic activity, insulin resistance and inflammatory processes and is now important to drug therapy and metabolism with relevance to prevention of drug-drug interactions. Sirt 1is involved in the deacetylation of the pregnane X receptor that is critical to drug metabolism and regulation of other transcription factors (deacetylation) are also linked to hepatic glucose, fatty acid and caffeine metabolism. Nutritional interventions are required to optimize drug therapy and improve therapeutic outcomes to reverse drug-drug interactions or drug-disease interactions in the current global chronic disease epidemic. Low calorie diets that activate Sirt 1 have become critical to prevent NAFLD, cardiovascular disease and neurodegeneration with consumption Sirt 1 activators important to maintain drug therapy and metabolism. Unhealthy diets that reduce drug metabolism increases the risk for chronic diseases with relevance to drug induced mitochondrial apoptosis in the liver, pancreas, heart and brain. In the developing world caffeine consumption should be assessed with relevance to the elevated levels of xenobiotic and LPS that may inactivate drug metabolism and accelerate drug induced mitochondrial apoptosis in these populations.

Original languageEnglish
Publication statusPublished - 13 Nov 2018
Event8th World Gene Convention -2017 - Macau, China
Duration: 13 Nov 201715 Nov 2017

Conference

Conference8th World Gene Convention -2017
CountryChina
CityMacau
Period13/11/1715/11/17

Fingerprint

Drug Interactions
Sirtuin 1
Chronic Disease
Pharmaceutical Preparations
Drug Therapy
Apoptosis
Cell Aging
Organelle Biogenesis
Caffeine
Insulin Resistance
Genes
Caloric Restriction
Histone Deacetylases
Drug and Narcotic Control
Liver
Brain Diseases
Xenobiotics
NAD
Population
Liver Diseases

Cite this

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title = "Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases",
abstract = "Drug therapy to stabilize insulin resistance and various chronic diseases that reverse cell senescence and apoptosis has been implemented in various global populations. The need to optimize drug therapy and improve therapeutic outcomes has become of major concern with relevance to alarming reports of drug-drug interactions or drug-disease interactions with relevance to the global chronic disease epidemic. In diseases of the heart, brain and liver cell senescence is now connected to mitochondrial apoptosis with nutrition of major importance in the maintenance of mitochondrial biogenesis and the prevention of NAFLD and obesity. The search for specific genes that maintain mitochondria biogenesis has identified the anti-aging gene Sirtuin 1 (Sirt 1) as the gene involved in mitochondrial biogenesis. Sirt 1 is a NAD+ dependent class III histone deacetylase activity involved in the regulation of metabolic activity, insulin resistance and inflammatory processes and is now important to drug therapy and metabolism with relevance to prevention of drug-drug interactions. Sirt 1is involved in the deacetylation of the pregnane X receptor that is critical to drug metabolism and regulation of other transcription factors (deacetylation) are also linked to hepatic glucose, fatty acid and caffeine metabolism. Nutritional interventions are required to optimize drug therapy and improve therapeutic outcomes to reverse drug-drug interactions or drug-disease interactions in the current global chronic disease epidemic. Low calorie diets that activate Sirt 1 have become critical to prevent NAFLD, cardiovascular disease and neurodegeneration with consumption Sirt 1 activators important to maintain drug therapy and metabolism. Unhealthy diets that reduce drug metabolism increases the risk for chronic diseases with relevance to drug induced mitochondrial apoptosis in the liver, pancreas, heart and brain. In the developing world caffeine consumption should be assessed with relevance to the elevated levels of xenobiotic and LPS that may inactivate drug metabolism and accelerate drug induced mitochondrial apoptosis in these populations.",
author = "Ian Martins",
year = "2018",
month = "11",
day = "13",
language = "English",
note = "8th World Gene Convention -2017 ; Conference date: 13-11-2017 Through 15-11-2017",

}

Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases. / Martins, Ian.

2018. Abstract from 8th World Gene Convention -2017, Macau, China.

Research output: Contribution to conferenceAbstract

TY - CONF

T1 - Drug-Drug Interactions with Relevance to Drug Induced Mitochondrial Toxicity and Accelerated Global Chronic Diseases

AU - Martins, Ian

PY - 2018/11/13

Y1 - 2018/11/13

N2 - Drug therapy to stabilize insulin resistance and various chronic diseases that reverse cell senescence and apoptosis has been implemented in various global populations. The need to optimize drug therapy and improve therapeutic outcomes has become of major concern with relevance to alarming reports of drug-drug interactions or drug-disease interactions with relevance to the global chronic disease epidemic. In diseases of the heart, brain and liver cell senescence is now connected to mitochondrial apoptosis with nutrition of major importance in the maintenance of mitochondrial biogenesis and the prevention of NAFLD and obesity. The search for specific genes that maintain mitochondria biogenesis has identified the anti-aging gene Sirtuin 1 (Sirt 1) as the gene involved in mitochondrial biogenesis. Sirt 1 is a NAD+ dependent class III histone deacetylase activity involved in the regulation of metabolic activity, insulin resistance and inflammatory processes and is now important to drug therapy and metabolism with relevance to prevention of drug-drug interactions. Sirt 1is involved in the deacetylation of the pregnane X receptor that is critical to drug metabolism and regulation of other transcription factors (deacetylation) are also linked to hepatic glucose, fatty acid and caffeine metabolism. Nutritional interventions are required to optimize drug therapy and improve therapeutic outcomes to reverse drug-drug interactions or drug-disease interactions in the current global chronic disease epidemic. Low calorie diets that activate Sirt 1 have become critical to prevent NAFLD, cardiovascular disease and neurodegeneration with consumption Sirt 1 activators important to maintain drug therapy and metabolism. Unhealthy diets that reduce drug metabolism increases the risk for chronic diseases with relevance to drug induced mitochondrial apoptosis in the liver, pancreas, heart and brain. In the developing world caffeine consumption should be assessed with relevance to the elevated levels of xenobiotic and LPS that may inactivate drug metabolism and accelerate drug induced mitochondrial apoptosis in these populations.

AB - Drug therapy to stabilize insulin resistance and various chronic diseases that reverse cell senescence and apoptosis has been implemented in various global populations. The need to optimize drug therapy and improve therapeutic outcomes has become of major concern with relevance to alarming reports of drug-drug interactions or drug-disease interactions with relevance to the global chronic disease epidemic. In diseases of the heart, brain and liver cell senescence is now connected to mitochondrial apoptosis with nutrition of major importance in the maintenance of mitochondrial biogenesis and the prevention of NAFLD and obesity. The search for specific genes that maintain mitochondria biogenesis has identified the anti-aging gene Sirtuin 1 (Sirt 1) as the gene involved in mitochondrial biogenesis. Sirt 1 is a NAD+ dependent class III histone deacetylase activity involved in the regulation of metabolic activity, insulin resistance and inflammatory processes and is now important to drug therapy and metabolism with relevance to prevention of drug-drug interactions. Sirt 1is involved in the deacetylation of the pregnane X receptor that is critical to drug metabolism and regulation of other transcription factors (deacetylation) are also linked to hepatic glucose, fatty acid and caffeine metabolism. Nutritional interventions are required to optimize drug therapy and improve therapeutic outcomes to reverse drug-drug interactions or drug-disease interactions in the current global chronic disease epidemic. Low calorie diets that activate Sirt 1 have become critical to prevent NAFLD, cardiovascular disease and neurodegeneration with consumption Sirt 1 activators important to maintain drug therapy and metabolism. Unhealthy diets that reduce drug metabolism increases the risk for chronic diseases with relevance to drug induced mitochondrial apoptosis in the liver, pancreas, heart and brain. In the developing world caffeine consumption should be assessed with relevance to the elevated levels of xenobiotic and LPS that may inactivate drug metabolism and accelerate drug induced mitochondrial apoptosis in these populations.

M3 - Abstract

ER -