Dramatic acceleration of reproductive aging, contraction of biochemical fecundity and healthspan-lifespan implications of opioid-induced endocrinopathy—FSH/LH ratio and other interrelationships

Albert Stuart Reece, Mervyn Rees Thomas, Amanda Norman, Gary Kenneth Hulse

    Research output: Contribution to journalArticle

    3 Citations (Scopus)

    Abstract

    Whilst disturbances of female reproductive hormones and function are commonplace in opioid dependence, their pathophysiological interrelationships are not well understood. Hormonal levels in females were compared in 77 opioid dependent patients (ODP) and 148 medical controls (MC) including 205 and 364 repeat studies. Significant changes in FSH, LH, oestradiol, testosterone and SBG were noted including power functions with age. The FSH/LH was lower in ODP (P = 0.0150) and the ratio inversion point occurred at 28.06 ± 9.36 v. 46.26 ± 4.76 years, implying a 58% reduction in fertility duration. FSH has been shown to induce ovarian failure and GnRH (controlling LH and FSH) has been shown to regulate longevity systemically. This implies that, far from being benign, these findings explicate the adverse experience of female compared to male ODP, exacerbate opioid-dependent aging amongst females, and informs the care of opioid dependent women, particularly relating to the choice, dose and duration of agonist or antagonist therapy.

    Original languageEnglish
    Pages (from-to)20-30
    Number of pages11
    JournalReproductive Toxicology
    Volume66
    DOIs
    Publication statusPublished - 1 Dec 2016

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