Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability

Wanting Dai, Huilong Guo, Bo Gao, Miaoliang Ruan, Lanqin Xu, Jianping Wu, Thomas Brett Kirk, Jiake Xu, Dong Ma, Wei Xue

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

In this work, near-infrared (NIR)-responsive double network shape memory hydrogels were formed by chemically cross-linking Pluronic F127 diacrylate macromer (F127DA) and physical blending of poly(lactide-co-glycolide) (PLGA) with graphene oxide (GO, an energy convertor to convert NIR irradiation to thermal energy). The hydrogels were manufactured with 3D-printing technology using ultraviolet light polymerization. The morphologies and crystalline structure of the hydrogels were determined by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The NIR and thermal activated shape memory properties, mechanical toughness, and cytotoxicity were investigated. The shape memory properties were improved by incorporating GO into the hydrogels and the mechanical properties were enhanced by the addition of PLGA, which served as a second network. The cytotoxicity was assessed by the CCK-8 assay, which revealed no cytotoxicity. The nontoxicity, high mechanical toughness (3.45 MPa in the swollen state), and biosafety at the shape recovery temperature (36 +/- 1 degrees C), which was achieved by NIR stimuli, indicates that shape memory hydrogels can be used in biomedical materials safely. The practical potential of the F127DA/PLGA/GO hydrogels was further revealed by their 3D-printing performance, their shape fixity ratio greater than 85%, and their shape recovery time under 300 s. Our results propose that F127DA/PLGA/GO hydrogels will be a promising material in biomedical applications as a drug carrier and an antibacterial scaffold.

Original languageEnglish
Pages (from-to)934-949
Number of pages16
JournalChemical Engineering Journal
Volume356
DOIs
Publication statusPublished - 15 Jan 2019

Cite this

Dai, Wanting ; Guo, Huilong ; Gao, Bo ; Ruan, Miaoliang ; Xu, Lanqin ; Wu, Jianping ; Kirk, Thomas Brett ; Xu, Jiake ; Ma, Dong ; Xue, Wei. / Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability. In: Chemical Engineering Journal. 2019 ; Vol. 356. pp. 934-949.
@article{6623699b4ebe4e60852cad8beb5d25d0,
title = "Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability",
abstract = "In this work, near-infrared (NIR)-responsive double network shape memory hydrogels were formed by chemically cross-linking Pluronic F127 diacrylate macromer (F127DA) and physical blending of poly(lactide-co-glycolide) (PLGA) with graphene oxide (GO, an energy convertor to convert NIR irradiation to thermal energy). The hydrogels were manufactured with 3D-printing technology using ultraviolet light polymerization. The morphologies and crystalline structure of the hydrogels were determined by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The NIR and thermal activated shape memory properties, mechanical toughness, and cytotoxicity were investigated. The shape memory properties were improved by incorporating GO into the hydrogels and the mechanical properties were enhanced by the addition of PLGA, which served as a second network. The cytotoxicity was assessed by the CCK-8 assay, which revealed no cytotoxicity. The nontoxicity, high mechanical toughness (3.45 MPa in the swollen state), and biosafety at the shape recovery temperature (36 +/- 1 degrees C), which was achieved by NIR stimuli, indicates that shape memory hydrogels can be used in biomedical materials safely. The practical potential of the F127DA/PLGA/GO hydrogels was further revealed by their 3D-printing performance, their shape fixity ratio greater than 85{\%}, and their shape recovery time under 300 s. Our results propose that F127DA/PLGA/GO hydrogels will be a promising material in biomedical applications as a drug carrier and an antibacterial scaffold.",
keywords = "Shape memory hydrogels, High mechanical toughness, 3D printability, Nontoxicity, Double network, NANOCOMPOSITE HYDROGELS, BIOMEDICAL APPLICATIONS, DRUG-DELIVERY, STRENGTH, COMPOSITE, RELEASE, FABRICATION, SCAFFOLD, PH, NANOSTRUCTURE",
author = "Wanting Dai and Huilong Guo and Bo Gao and Miaoliang Ruan and Lanqin Xu and Jianping Wu and Kirk, {Thomas Brett} and Jiake Xu and Dong Ma and Wei Xue",
year = "2019",
month = "1",
day = "15",
doi = "10.1016/j.cej.2018.09.078",
language = "English",
volume = "356",
pages = "934--949",
journal = "Chemical Engineering Journal",
issn = "1385-8947",
publisher = "Elsevier Science & Technology",

}

Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability. / Dai, Wanting; Guo, Huilong; Gao, Bo; Ruan, Miaoliang; Xu, Lanqin; Wu, Jianping; Kirk, Thomas Brett; Xu, Jiake; Ma, Dong; Xue, Wei.

In: Chemical Engineering Journal, Vol. 356, 15.01.2019, p. 934-949.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Double network shape memory hydrogels activated by near-infrared with high mechanical toughness, nontoxicity, and 3D printability

AU - Dai, Wanting

AU - Guo, Huilong

AU - Gao, Bo

AU - Ruan, Miaoliang

AU - Xu, Lanqin

AU - Wu, Jianping

AU - Kirk, Thomas Brett

AU - Xu, Jiake

AU - Ma, Dong

AU - Xue, Wei

PY - 2019/1/15

Y1 - 2019/1/15

N2 - In this work, near-infrared (NIR)-responsive double network shape memory hydrogels were formed by chemically cross-linking Pluronic F127 diacrylate macromer (F127DA) and physical blending of poly(lactide-co-glycolide) (PLGA) with graphene oxide (GO, an energy convertor to convert NIR irradiation to thermal energy). The hydrogels were manufactured with 3D-printing technology using ultraviolet light polymerization. The morphologies and crystalline structure of the hydrogels were determined by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The NIR and thermal activated shape memory properties, mechanical toughness, and cytotoxicity were investigated. The shape memory properties were improved by incorporating GO into the hydrogels and the mechanical properties were enhanced by the addition of PLGA, which served as a second network. The cytotoxicity was assessed by the CCK-8 assay, which revealed no cytotoxicity. The nontoxicity, high mechanical toughness (3.45 MPa in the swollen state), and biosafety at the shape recovery temperature (36 +/- 1 degrees C), which was achieved by NIR stimuli, indicates that shape memory hydrogels can be used in biomedical materials safely. The practical potential of the F127DA/PLGA/GO hydrogels was further revealed by their 3D-printing performance, their shape fixity ratio greater than 85%, and their shape recovery time under 300 s. Our results propose that F127DA/PLGA/GO hydrogels will be a promising material in biomedical applications as a drug carrier and an antibacterial scaffold.

AB - In this work, near-infrared (NIR)-responsive double network shape memory hydrogels were formed by chemically cross-linking Pluronic F127 diacrylate macromer (F127DA) and physical blending of poly(lactide-co-glycolide) (PLGA) with graphene oxide (GO, an energy convertor to convert NIR irradiation to thermal energy). The hydrogels were manufactured with 3D-printing technology using ultraviolet light polymerization. The morphologies and crystalline structure of the hydrogels were determined by scanning electron microscopy (SEM) and X-ray diffraction (XRD). The NIR and thermal activated shape memory properties, mechanical toughness, and cytotoxicity were investigated. The shape memory properties were improved by incorporating GO into the hydrogels and the mechanical properties were enhanced by the addition of PLGA, which served as a second network. The cytotoxicity was assessed by the CCK-8 assay, which revealed no cytotoxicity. The nontoxicity, high mechanical toughness (3.45 MPa in the swollen state), and biosafety at the shape recovery temperature (36 +/- 1 degrees C), which was achieved by NIR stimuli, indicates that shape memory hydrogels can be used in biomedical materials safely. The practical potential of the F127DA/PLGA/GO hydrogels was further revealed by their 3D-printing performance, their shape fixity ratio greater than 85%, and their shape recovery time under 300 s. Our results propose that F127DA/PLGA/GO hydrogels will be a promising material in biomedical applications as a drug carrier and an antibacterial scaffold.

KW - Shape memory hydrogels

KW - High mechanical toughness

KW - 3D printability

KW - Nontoxicity

KW - Double network

KW - NANOCOMPOSITE HYDROGELS

KW - BIOMEDICAL APPLICATIONS

KW - DRUG-DELIVERY

KW - STRENGTH

KW - COMPOSITE

KW - RELEASE

KW - FABRICATION

KW - SCAFFOLD

KW - PH

KW - NANOSTRUCTURE

U2 - 10.1016/j.cej.2018.09.078

DO - 10.1016/j.cej.2018.09.078

M3 - Article

VL - 356

SP - 934

EP - 949

JO - Chemical Engineering Journal

JF - Chemical Engineering Journal

SN - 1385-8947

ER -