Dosimetry, clinical factors and medication intake influencing urinary symptoms after prostate radiotherapy: An analysis of data from the RADAR prostate radiotherapy trial

N. Yahya, Martin Ebert, M. Bulsara, A. Haworth, A. Kennedy, David Joseph, J.W. Denham

    Research output: Contribution to journalArticle

    18 Citations (Scopus)

    Abstract

    © 2015 Elsevier Ireland Ltd. Abstract Purpose/objective To identify dosimetry, clinical factors and medication intake impacting urinary symptoms after prostate radiotherapy. Material and methods Data describing clinical factors and bladder dosimetry (reduced with principal component (PC) analysis) for 754 patients treated with external beam radiotherapy accrued by TROG 03.04 RADAR prostate radiotherapy trial were available for analysis. Urinary symptoms (frequency, incontinence, dysuria and haematuria) were prospectively assessed using LENT-SOMA to a median of 72 months. The endpoints assessed were prevalence (grade ≥1) at the end of radiotherapy (representing acute symptoms), at 18-, 36- and 54-month follow-ups (representing late symptoms) and peak late incidence including only grade ≥2. Impact of factors was assessed using multivariate logistic regression models with correction for over-optimism. Results Baseline symptoms, non-insulin dependent diabetes mellitus, age and PC1 (correlated to the mean dose) impact symptoms at >1 timepoints. Associations at a single timepoint were found for cerebrovascular condition, ECOG status and non-steroidal anti-inflammatory drug intake. Peak incidence analysis shows the impact of baseline, bowel and cerebrovascular condition and smoking status. Conclusions The prevalence and incidence analysis provide a complementary view for urinary symptom prediction. Sustained impacts across time points were found for several factors while some associations were not repeated at different time points suggesting poorer or transient impact.
    Original languageEnglish
    Pages (from-to)112-118
    Number of pages7
    JournalRadiotherapy and Oncology
    Volume116
    Issue number1
    DOIs
    Publication statusPublished - 7 Jul 2015

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