Domino reactions in the synthesis of n-heterocycles and total synthesis of the antitumor anthraquionone natural product (±)BE-26554A

James Rixson

Research output: ThesisDoctoral Thesis

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Abstract

This thesis describes the development of palladium catalysed domino reactions to form 3-benzazepines and isoquinolines; a unique carbopallidation-carbonylative-annulation reaction to give anthra-2-pyranones and the total synthesis of the natural product (±)BE-26554A via a unique beta-keto-sulfoxide-aldehyde-annulation domino reaction as the key synthetic step. A series of cancer growth inhibiting analogues were also synthesed. N-Heterocycles and Total Synthesis of the Antitumor Anthraquionone Natural Product (±)BE-26554A
Original languageEnglish
QualificationDoctor of Philosophy
Awarding Institution
  • The University of Western Australia
Award date24 May 2019
DOIs
Publication statusUnpublished - 2019

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