A series of methods for palladium-mediated single-step and domino Tsuji–Trost/Heck reactions are described. These methods are applied to the synthesis of both 3-benzazepines and azepino[4,5-b]indoles in the category of complex 6-7-6 and 6-5-7 ring heterocycles. In addition, a domino Heck/Heck sequence of reactions that produces the azepinobenzindolizine tetracyclic ring system from N-diallylated precursors is described.
Stewart, S., Heath, C., & Ghisalberti, E. (2009). Domino or Single-Step Tsuji-Trost/Heck Reactions and Their Application in the Synthesis of 3-Benzazepines and Azepino[4,5-b]indole Ring Systems. European Journal of Organic Chemistry, 2009(12), 1934-1943. https://doi.org/10.1002/ejoc.200900028