DOES ASPIRIN AFFECT THE RATE OF CATARACT FORMATION - CROSS-SECTIONAL RESULTS DURING A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL TO PREVENT SERIOUS VASCULAR EVENTS

GJ HANKEY, S RICHARDS, C WARLOW

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11 Citations (Scopus)

Abstract

A total of 2435 patients with transient ischaemic attack or Minor ischaemic stroke were entered into the UK-TIA aspirin trial and randomised to treatment with aspirin 1200 mg/day, aspirin 300 mg/day, or placebo. At a single point in time during the trial patients were examined ophthalmoscopically for evidence of cataracts. The length of time that each patient had been participating in the trial at the time of ophthalmic examination varied from 1 to 5 years. The prevalence of cataracts was similar in patients allocated aspirin and patients allocated placebo irrespective of the length of time that they had been in the trial. These findings suggest that aspirin taken in a dose of 300 to 1200 mg daily for a few years does not prevent cataracts.

Original languageEnglish
Pages (from-to)259-261
Number of pages3
JournalBritish Journal of Ophthalmology
Volume76
Issue number5
Publication statusPublished - May 1992

Cite this

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title = "DOES ASPIRIN AFFECT THE RATE OF CATARACT FORMATION - CROSS-SECTIONAL RESULTS DURING A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL TO PREVENT SERIOUS VASCULAR EVENTS",
abstract = "A total of 2435 patients with transient ischaemic attack or Minor ischaemic stroke were entered into the UK-TIA aspirin trial and randomised to treatment with aspirin 1200 mg/day, aspirin 300 mg/day, or placebo. At a single point in time during the trial patients were examined ophthalmoscopically for evidence of cataracts. The length of time that each patient had been participating in the trial at the time of ophthalmic examination varied from 1 to 5 years. The prevalence of cataracts was similar in patients allocated aspirin and patients allocated placebo irrespective of the length of time that they had been in the trial. These findings suggest that aspirin taken in a dose of 300 to 1200 mg daily for a few years does not prevent cataracts.",
keywords = "POSSIBLE MECHANISM, LENS, SALICYLATE, INVITRO",
author = "GJ HANKEY and S RICHARDS and C WARLOW",
year = "1992",
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language = "English",
volume = "76",
pages = "259--261",
journal = "British Journal of Opthalmology",
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TY - JOUR

T1 - DOES ASPIRIN AFFECT THE RATE OF CATARACT FORMATION - CROSS-SECTIONAL RESULTS DURING A RANDOMIZED DOUBLE-BLIND PLACEBO CONTROLLED TRIAL TO PREVENT SERIOUS VASCULAR EVENTS

AU - HANKEY, GJ

AU - RICHARDS, S

AU - WARLOW, C

PY - 1992/5

Y1 - 1992/5

N2 - A total of 2435 patients with transient ischaemic attack or Minor ischaemic stroke were entered into the UK-TIA aspirin trial and randomised to treatment with aspirin 1200 mg/day, aspirin 300 mg/day, or placebo. At a single point in time during the trial patients were examined ophthalmoscopically for evidence of cataracts. The length of time that each patient had been participating in the trial at the time of ophthalmic examination varied from 1 to 5 years. The prevalence of cataracts was similar in patients allocated aspirin and patients allocated placebo irrespective of the length of time that they had been in the trial. These findings suggest that aspirin taken in a dose of 300 to 1200 mg daily for a few years does not prevent cataracts.

AB - A total of 2435 patients with transient ischaemic attack or Minor ischaemic stroke were entered into the UK-TIA aspirin trial and randomised to treatment with aspirin 1200 mg/day, aspirin 300 mg/day, or placebo. At a single point in time during the trial patients were examined ophthalmoscopically for evidence of cataracts. The length of time that each patient had been participating in the trial at the time of ophthalmic examination varied from 1 to 5 years. The prevalence of cataracts was similar in patients allocated aspirin and patients allocated placebo irrespective of the length of time that they had been in the trial. These findings suggest that aspirin taken in a dose of 300 to 1200 mg daily for a few years does not prevent cataracts.

KW - POSSIBLE MECHANISM

KW - LENS

KW - SALICYLATE

KW - INVITRO

M3 - Article

VL - 76

SP - 259

EP - 261

JO - British Journal of Opthalmology

JF - British Journal of Opthalmology

SN - 0007-1161

IS - 5

ER -