DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

J.R.B. Perry; Y. Hsu; D.I. Chasman; A.D. Johnson; C.E. Elks; E. Albrecht; I.L.I.L. Andrulis; J. Beesley; G.S. Berenson; S.M. Bergmann; S.E. Bojesen; M.K. Bolla; J.W.S. Brown; J.E. Buring; H.S. Campbell; J.C. Chang-Claude; G. Chenevix-Trench; T. Corre; F.J. Couch; A.J.R. Cox; K. Czene; A.P. D'Adamo; G.C. Davies; I.J. Deary; J. Dennis; D.F. Easton; E.G. Engelhardt; J.G. Eriksson; T. Esko; P.A. Fasching; J.D. Figueroa; H.L. Flyger; A. Fraser; M. García-Closas; P. Gasparini; C. Gieger; G.G. Giles; P. Guénel; S. Hägg; P.F.L. Hall; C. Hayward; J.L. Hopper; E. Ingelsson; S. Kardia; K. Kasiman; J.A. Knight; J. Lahti; D.A. Lawlor; P.K.E. Magnusson; S. Margolin; Julie Marsh; A.K. Metspalu; J.E. Olson; Craig Pennell; O. Polašek; I.A.S. Rahman; P.M. Ridker; A. Robino; I. Rudan; A. Rudolph; A. Salumets; M.K. Schmidt; M.J. Schoemaker; E.N. Smith; J.A. Smith; M.C. Southey; D. Stöckl; A.J. Swerdlow; D.J. Thompson; T. Truong; S. Ulivi; M. Waldenberger; Q. Wang; S.H. Wild; J.F. Wilson; A.F. Wright; L. Zgaga; K. Ong; J.M. Murabito; D. Karasik; A. Murray

doi:10.1093/hmg/ddt620

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

J.R.B. Perry, Y. Hsu, D.I. Chasman, A.D. Johnson, C.E. Elks, E. Albrecht, I.L.I.L. Andrulis, J. Beesley, G.S. Berenson, S.M. Bergmann, S.E. Bojesen, M.K. Bolla, J.W.S. Brown, J.E. Buring, H.S. Campbell, J.C. Chang-Claude, G. Chenevix-Trench, T. Corre, F.J. Couch, A.J.R. CoxK. Czene, A.P. D'Adamo, G.C. Davies, I.J. Deary, J. Dennis, D.F. Easton, E.G. Engelhardt, J.G. Eriksson, T. Esko, P.A. Fasching, J.D. Figueroa, H.L. Flyger, A. Fraser, M. García-Closas, P. Gasparini, C. Gieger, G.G. Giles, P. Guénel, S. Hägg, P.F.L. Hall, C. Hayward, J.L. Hopper, E. Ingelsson, S. Kardia, K. Kasiman, J.A. Knight, J. Lahti, D.A. Lawlor, P.K.E. Magnusson, S. Margolin, Julie Marsh, A.K. Metspalu, J.E. Olson, Craig Pennell, O. Polašek, I.A.S. Rahman, P.M. Ridker, A. Robino, I. Rudan, A. Rudolph, A. Salumets, M.K. Schmidt, M.J. Schoemaker, E.N. Smith, J.A. Smith, M.C. Southey, D. Stöckl, A.J. Swerdlow, D.J. Thompson, T. Truong, S. Ulivi, M. Waldenberger, Q. Wang, S.H. Wild, J.F. Wilson, A.F. Wright, L. Zgaga, K. Ong, J.M. Murabito, D. Karasik, A. Murray

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Abstract

The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ~50% of the variation in both age atmenarche andmenopause, but to date theknowngenes explain

Original language	English
Pages (from-to)	2490-2497
Journal	Human Molecular Genetics
Volume	23
Issue number	9
DOIs	https://doi.org/10.1093/hmg/ddt620
Publication status	Published - 2014

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10.1093/hmg/ddt620

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Perry, J. R. B., Hsu, Y., Chasman, D. I., Johnson, A. D., Elks, C. E., Albrecht, E., Andrulis, I. L. I. L., Beesley, J., Berenson, G. S., Bergmann, S. M., Bojesen, S. E., Bolla, M. K., Brown, J. W. S., Buring, J. E., Campbell, H. S., Chang-Claude, J. C., Chenevix-Trench, G., Corre, T., Couch, F. J., ... Murray, A. (2014). DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Human Molecular Genetics, 23(9), 2490-2497. https://doi.org/10.1093/hmg/ddt620

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title = "DNA mismatch repair gene MSH6 implicated in determining age at natural menopause",

abstract = "The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ~50% of the variation in both age atmenarche andmenopause, but to date theknowngenes explain",

author = "J.R.B. Perry and Y. Hsu and D.I. Chasman and A.D. Johnson and C.E. Elks and E. Albrecht and I.L.I.L. Andrulis and J. Beesley and G.S. Berenson and S.M. Bergmann and S.E. Bojesen and M.K. Bolla and J.W.S. Brown and J.E. Buring and H.S. Campbell and J.C. Chang-Claude and G. Chenevix-Trench and T. Corre and F.J. Couch and A.J.R. Cox and K. Czene and A.P. D'Adamo and G.C. Davies and I.J. Deary and J. Dennis and D.F. Easton and E.G. Engelhardt and J.G. Eriksson and T. Esko and P.A. Fasching and J.D. Figueroa and H.L. Flyger and A. Fraser and M. Garc{\'i}a-Closas and P. Gasparini and C. Gieger and G.G. Giles and P. Gu{\'e}nel and S. H{\"a}gg and P.F.L. Hall and C. Hayward and J.L. Hopper and E. Ingelsson and S. Kardia and K. Kasiman and J.A. Knight and J. Lahti and D.A. Lawlor and P.K.E. Magnusson and S. Margolin and Julie Marsh and A.K. Metspalu and J.E. Olson and Craig Pennell and O. Pola{\v s}ek and I.A.S. Rahman and P.M. Ridker and A. Robino and I. Rudan and A. Rudolph and A. Salumets and M.K. Schmidt and M.J. Schoemaker and E.N. Smith and J.A. Smith and M.C. Southey and D. St{\"o}ckl and A.J. Swerdlow and D.J. Thompson and T. Truong and S. Ulivi and M. Waldenberger and Q. Wang and S.H. Wild and J.F. Wilson and A.F. Wright and L. Zgaga and K. Ong and J.M. Murabito and D. Karasik and A. Murray",

year = "2014",

doi = "10.1093/hmg/ddt620",

language = "English",

volume = "23",

pages = "2490--2497",

journal = "Human Molecular Genetics",

issn = "0964-6906",

publisher = "Oxford University Press",

number = "9",

}

Perry, JRB, Hsu, Y, Chasman, DI, Johnson, AD, Elks, CE, Albrecht, E, Andrulis, ILIL, Beesley, J, Berenson, GS, Bergmann, SM, Bojesen, SE, Bolla, MK, Brown, JWS, Buring, JE, Campbell, HS, Chang-Claude, JC, Chenevix-Trench, G, Corre, T, Couch, FJ, Cox, AJR, Czene, K, D'Adamo, AP, Davies, GC, Deary, IJ, Dennis, J, Easton, DF, Engelhardt, EG, Eriksson, JG, Esko, T, Fasching, PA, Figueroa, JD, Flyger, HL, Fraser, A, García-Closas, M, Gasparini, P, Gieger, C, Giles, GG, Guénel, P, Hägg, S, Hall, PFL, Hayward, C, Hopper, JL, Ingelsson, E, Kardia, S, Kasiman, K, Knight, JA, Lahti, J, Lawlor, DA, Magnusson, PKE, Margolin, S, Marsh, J, Metspalu, AK, Olson, JE, Pennell, C, Polašek, O, Rahman, IAS, Ridker, PM, Robino, A, Rudan, I, Rudolph, A, Salumets, A, Schmidt, MK, Schoemaker, MJ, Smith, EN, Smith, JA, Southey, MC, Stöckl, D, Swerdlow, AJ, Thompson, DJ, Truong, T, Ulivi, S, Waldenberger, M, Wang, Q, Wild, SH, Wilson, JF, Wright, AF, Zgaga, L, Ong, K, Murabito, JM, Karasik, D & Murray, A 2014, 'DNA mismatch repair gene MSH6 implicated in determining age at natural menopause', Human Molecular Genetics, vol. 23, no. 9, pp. 2490-2497. https://doi.org/10.1093/hmg/ddt620

TY - JOUR

T1 - DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

AU - Perry, J.R.B.

AU - Hsu, Y.

AU - Chasman, D.I.

AU - Johnson, A.D.

AU - Elks, C.E.

AU - Albrecht, E.

AU - Andrulis, I.L.I.L.

AU - Beesley, J.

AU - Berenson, G.S.

AU - Bergmann, S.M.

AU - Bojesen, S.E.

AU - Bolla, M.K.

AU - Brown, J.W.S.

AU - Buring, J.E.

AU - Campbell, H.S.

AU - Chang-Claude, J.C.

AU - Chenevix-Trench, G.

AU - Corre, T.

AU - Couch, F.J.

AU - Cox, A.J.R.

AU - Czene, K.

AU - D'Adamo, A.P.

AU - Davies, G.C.

AU - Deary, I.J.

AU - Dennis, J.

AU - Easton, D.F.

AU - Engelhardt, E.G.

AU - Eriksson, J.G.

AU - Esko, T.

AU - Fasching, P.A.

AU - Figueroa, J.D.

AU - Flyger, H.L.

AU - Fraser, A.

AU - García-Closas, M.

AU - Gasparini, P.

AU - Gieger, C.

AU - Giles, G.G.

AU - Guénel, P.

AU - Hägg, S.

AU - Hall, P.F.L.

AU - Hayward, C.

AU - Hopper, J.L.

AU - Ingelsson, E.

AU - Kardia, S.

AU - Kasiman, K.

AU - Knight, J.A.

AU - Lahti, J.

AU - Lawlor, D.A.

AU - Magnusson, P.K.E.

AU - Margolin, S.

AU - Marsh, Julie

AU - Metspalu, A.K.

AU - Olson, J.E.

AU - Pennell, Craig

AU - Polašek, O.

AU - Rahman, I.A.S.

AU - Ridker, P.M.

AU - Robino, A.

AU - Rudan, I.

AU - Rudolph, A.

AU - Salumets, A.

AU - Schmidt, M.K.

AU - Schoemaker, M.J.

AU - Smith, E.N.

AU - Smith, J.A.

AU - Southey, M.C.

AU - Stöckl, D.

AU - Swerdlow, A.J.

AU - Thompson, D.J.

AU - Truong, T.

AU - Ulivi, S.

AU - Waldenberger, M.

AU - Wang, Q.

AU - Wild, S.H.

AU - Wilson, J.F.

AU - Wright, A.F.

AU - Zgaga, L.

AU - Ong, K.

AU - Murabito, J.M.

AU - Karasik, D.

AU - Murray, A.

PY - 2014

Y1 - 2014

N2 - The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ~50% of the variation in both age atmenarche andmenopause, but to date theknowngenes explain

AB - The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ~50% of the variation in both age atmenarche andmenopause, but to date theknowngenes explain

U2 - 10.1093/hmg/ddt620

DO - 10.1093/hmg/ddt620

M3 - Article

SN - 0964-6906

VL - 23

SP - 2490

EP - 2497

JO - Human Molecular Genetics

JF - Human Molecular Genetics

IS - 9

ER -

DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

Abstract

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