DNA mismatch repair gene MSH6 implicated in determining age at natural menopause

J.R.B. Perry, Y. Hsu, D.I. Chasman, A.D. Johnson, C.E. Elks, E. Albrecht, I.L.I.L. Andrulis, J. Beesley, G.S. Berenson, S.M. Bergmann, S.E. Bojesen, M.K. Bolla, J.W.S. Brown, J.E. Buring, H.S. Campbell, J.C. Chang-Claude, G. Chenevix-Trench, T. Corre, F.J. Couch, A.J.R. CoxK. Czene, A.P. D'Adamo, G.C. Davies, I.J. Deary, J. Dennis, D.F. Easton, E.G. Engelhardt, J.G. Eriksson, T. Esko, P.A. Fasching, J.D. Figueroa, H.L. Flyger, A. Fraser, M. García-Closas, P. Gasparini, C. Gieger, G.G. Giles, P. Guénel, S. Hägg, P.F.L. Hall, C. Hayward, J.L. Hopper, E. Ingelsson, S. Kardia, K. Kasiman, J.A. Knight, J. Lahti, D.A. Lawlor, P.K.E. Magnusson, S. Margolin, Julie Marsh, A.K. Metspalu, J.E. Olson, Craig Pennell, O. Polašek, I.A.S. Rahman, P.M. Ridker, A. Robino, I. Rudan, A. Rudolph, A. Salumets, M.K. Schmidt, M.J. Schoemaker, E.N. Smith, J.A. Smith, M.C. Southey, D. Stöckl, A.J. Swerdlow, D.J. Thompson, T. Truong, S. Ulivi, M. Waldenberger, Q. Wang, S.H. Wild, J.F. Wilson, A.F. Wright, L. Zgaga, K. Ong, J.M. Murabito, D. Karasik, A. Murray

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Abstract

The length of female reproductive lifespan is associated with multiple adverse outcomes, including breast cancer, cardiovascular disease and infertility. The biological processes that govern the timing of the beginning and end of reproductive life are not well understood. Genetic variants are known to contribute to ~50% of the variation in both age atmenarche andmenopause, but to date theknowngenes explain
Original languageEnglish
Pages (from-to)2490-2497
JournalHuman Molecular Genetics
Volume23
Issue number9
DOIs
Publication statusPublished - 2014

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    Perry, J. R. B., Hsu, Y., Chasman, D. I., Johnson, A. D., Elks, C. E., Albrecht, E., ... Murray, A. (2014). DNA mismatch repair gene MSH6 implicated in determining age at natural menopause. Human Molecular Genetics, 23(9), 2490-2497. https://doi.org/10.1093/hmg/ddt620