DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells

Jessica King, Kelly Irving, Cameron W. Evans, Rupesh Chikhale, Rouven Becker, Christopher Morris, Cristian Peña Martinez, Peter Schofield, Daniel Christ, Laurence Hurley, Zoë Waller, Killugudi Swaminatha Iyer, Nicole Smith

Research output: Contribution to journalArticlepeer-review

32 Citations (Scopus)

Abstract

Guanine- and cytosine-rich nucleic acid sequences have the potential to form secondary structures such as G-quadruplexes and i-motifs, respectively. We show that stabilization of G-quadruplexes using small molecules destabilizes the i-motifs, and vice versa, indicating these gene regulatory controllers are interdependent in human cells. This has important implications as these structures are predominately considered as isolated structural targets for therapy, but their interdependency highlights the interplay of both structures as an important gene regulatory switch.
Original languageEnglish
Pages (from-to)20600-20604
Number of pages5
JournalJournal of the Amercian Chemical Society
Volume142
Issue number49
DOIs
Publication statusPublished - 9 Dec 2020

Fingerprint

Dive into the research topics of 'DNA G-Quadruplex and i-Motif Structure Formation Is Interdependent in Human Cells'. Together they form a unique fingerprint.

Cite this