Diversity in Guanine-Selective DNA Binding Modes for an Organometallic Ruthenium Arene Complex

H-K. Liu; Susan Berners-Price; F. Wang; J.A. Parkinson; J. Xu; J. Bella; P.J. Sadler

doi:10.1002/anie.200602873

Diversity in Guanine-Selective DNA Binding Modes for an Organometallic Ruthenium Arene Complex

H-K. Liu, Susan Berners-Price, F. Wang, J.A. Parkinson, J. Xu, J. Bella, P.J. Sadler

School of Molecular Sciences

Research output: Contribution to journal › Article › peer-review

142 Citations (Scopus)

Abstract

Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the noncoordinated phenyl ring of its arene ligand (yellow) between bases in the double helix.

Original language	English
Pages (from-to)	8153-8156
Journal	Angewandte Chemie (International Edition)
Volume	45
Issue number	48
DOIs	https://doi.org/10.1002/anie.200602873
Publication status	Published - 2006

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10.1002/anie.200602873

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title = "Diversity in Guanine-Selective DNA Binding Modes for an Organometallic Ruthenium Arene Complex",

abstract = "Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the noncoordinated phenyl ring of its arene ligand (yellow) between bases in the double helix.",

author = "H-K. Liu and Susan Berners-Price and F. Wang and J.A. Parkinson and J. Xu and J. Bella and P.J. Sadler",

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AU - Liu, H-K.

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AU - Parkinson, J.A.

AU - Xu, J.

AU - Bella, J.

AU - Sadler, P.J.

PY - 2006

Y1 - 2006

N2 - Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the noncoordinated phenyl ring of its arene ligand (yellow) between bases in the double helix.

AB - Seek and hide! An organometallic ruthenium arene anticancer complex with ruthenium (pink ball) chelated by ethylenediamine (blue) is selective for guanine bases on DNA and can bury the noncoordinated phenyl ring of its arene ligand (yellow) between bases in the double helix.

U2 - 10.1002/anie.200602873

DO - 10.1002/anie.200602873

M3 - Article

C2 - 17120267

VL - 45

SP - 8153

EP - 8156

JO - Angewandte Chemie - International Edition

JF - Angewandte Chemie - International Edition

SN - 1433-7851

IS - 48

ER -

Diversity in Guanine-Selective DNA Binding Modes for an Organometallic Ruthenium Arene Complex

Abstract

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