Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story

Jenefer Blackwell; S. Searle; H. Mohamed; J.K. White

doi:10.1016/S0165-2478(02)00231-6

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story

Jenefer Blackwell, S. Searle, H. Mohamed, J.K. White

UWA Centre for Child Health Research (affiliated with the The Kids Research Institute Australia)

Research output: Contribution to journal › Review article › peer-review

129 Citations (Scopus)

Abstract

Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages: (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1 and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.

Original language	English
Pages (from-to)	197-203
Journal	Immunology Letters
Volume	85
Issue number	2
DOIs	https://doi.org/10.1016/S0165-2478(02)00231-6
Publication status	Published - 2003

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title = "Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story",

abstract = "Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages: (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1 and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.",

author = "Jenefer Blackwell and S. Searle and H. Mohamed and J.K. White",

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T1 - Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story

AU - Blackwell, Jenefer

AU - Searle, S.

AU - Mohamed, H.

AU - White, J.K.

PY - 2003

Y1 - 2003

N2 - Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages: (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1 and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.

AB - Solute carrier family 11 member a1 (Slc11a1), formerly known as Nramp1/Ity/Lsh/Bcg, is a proton/divalent cation antiporter that regulates susceptibility to infectious and autoimmune disease. Here we review recent studies on (1) the role of Slc11a1 in iron metabolism and iron recycling in macrophages: (2) the use of mouse breeding and introgression of knockouts onto Slc11a1 congenic backgrounds for genes encoding the multiple pleiotropic functions associated with Slc11a1 and (3) associations/linkages of SLC11A1 with human disease and how these relate to functional promoter region polymorphisms. (C) 2002 Elsevier Science B.V. All rights reserved.

U2 - 10.1016/S0165-2478(02)00231-6

DO - 10.1016/S0165-2478(02)00231-6

M3 - Review article

SN - 0165-2478

VL - 85

SP - 197

EP - 203

JO - Immunology Letters

JF - Immunology Letters

IS - 2

ER -

Divalent cation transport and susceptibility to infectious and autoimmune disease: continuation of the Ity/Lsh/Bcg/Nramp1/Slc11a1 gene story

Abstract

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