Distribution of interferon lambda-3 gene polymorphisms in Australian patients with previously untreated genotype 1 chronic hepatitis C: Analysis from the PREDICT and CHARIOT studies

Stuart Roberts, Joanne Mitchell, Reynold Leung, David Booth, Steven Bollipo, George Ostapowicz, Andrew Sloss, Geoffrey W. Mccaughan, Gregory J. Dore, Alexander Thompson, Darrell Hg Crawford, William Sievert, Martin Weltman, Wendy Cheng, Jacob George, Peter Angus, Geoff Chu, Mark Cornwall, Darrell Crawford, Mark DouglasRichard Hallinan, Mazhar Haque, Glenn Hawkin, Hugh Jackson, Richard Johnson, Ian Kronborg, Alice Lee, Barbara Leggett, Marc Le Mire, Miriam Levy, John Lubel, Gerry MacQuillan, John Masson, Geoff McCaughan, Jenny McDonald, Bruce McGarity, Lindsay Mollison, Amanda Nicoll, John Ombiga, Stephen Riordan, Stuart Roberts, Simone Strasser, Alex Thompson, Jon Watson, John Wenman, Alan Wigg, Amany Zekry

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8 Citations (Scopus)

Abstract

Background and Aims: The aim of this study was to examine the distribution of interferon lambda-3 (IFN-λ3) gene polymorphisms in previously untreated Australian patients with genotype 1 (Gt1) chronic hepatitis C (CHC) and to compare the IFN-λ3 genotype frequency among the different ethnic populations. Methods: This was a prospective, multicenter, observational study undertaken by the Australian Liver Association Clinical Research Network. Eligible subjects had Gt1 CHC and were being considered for and/or undergoing treatment. IFN-λ3 single nucleotide polymorphisms were genotyped by the Applied Biosystems's Taqman single nucleotide polymorphism genotyping assay. Results: Between May 2012 and June 2012, 1132 patients were recruited from 38 treatment clinics across Australia. Also, 561 subjects from the CHARIOT (collaborative group hepatitis C study using high dose Pegasys RBV Induction dose in genotype one) study of high-dose interferon who had baseline serum available were retrospectively tested. The overall frequency of IFN-λ3 rs12979860 CC/CT/TT genotypes was 36%, 52%, and 12%, and that of rs8099917 TT/TG/GG genotypes was 54%, 41%, and 5%, respectively. The prevalence of the favorable IFN-λ3 rs12979860 CC and rs8099917 TT genotypes in Causcasians, Asians, Aboriginals, Maori/Pacific Islanders, and Mediterraneans was 32% and 52%, 80% and 86%, 33% and 63%, 77% and 88%, and 19% and 29%, respectively. Compared with Caucasians, the frequency of IFN-λ3 CC was significantly higher among Asians (P<0.0001) and Maori/Pacific Islander subjects (P<0.0001). Conclusions: The distribution of IFN-λ3 polymorphisms among untreated patients with Gt1 CHC in Australia appears similar to that reported from North America. The frequency of the favorable response alleles varies considerably according to ethnicity, being more common in self-reported Asians and Maori/Pacific Islanders than Caucasians, Aboriginals, and Mediterraneans.

Original languageEnglish
Pages (from-to)179-184
Number of pages6
JournalJournal of Gastroenterology and Hepatology (Australia)
Volume29
Issue number1
DOIs
Publication statusPublished - 1 Jan 2014
Externally publishedYes

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