Abstract
A cellobio-derived isofagomine glycosidase inhibitor (Ki 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.
Original language | English |
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Pages (from-to) | 946-947 |
Journal | Chemical Communications |
Volume | 8 |
Issue number | 8 |
Publication status | Published - 2003 |