Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

A. Varrot, J. Macdonald, Robert Stick, G. Pell, H.J. Gilbert, G.J. Davies

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

A cellobio-derived isofagomine glycosidase inhibitor (Ki 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.
Original languageEnglish
Pages (from-to)946-947
JournalChemical Communications
Volume8
Issue number8
Publication statusPublished - 2003

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