Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

A. Varrot; J. Macdonald; Robert Stick; G. Pell; H.J. Gilbert; G.J. Davies

Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

A. Varrot, J. Macdonald, Robert Stick, G. Pell, H.J. Gilbert, G.J. Davies

Research output: Contribution to journal › Article

Abstract

A cellobio-derived isofagomine glycosidase inhibitor (Ki 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

Original language	English
Pages (from-to)	946-947
Journal	Chemical Communications
Volume	8
Issue number	8
Publication status	Published - 2003

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title = "Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases",

abstract = "A cellobio-derived isofagomine glycosidase inhibitor (Ki 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.",

author = "A. Varrot and J. Macdonald and Robert Stick and G. Pell and H.J. Gilbert and G.J. Davies",

year = "2003",

language = "English",

volume = "8",

pages = "946--947",

journal = "Chemical Communications, 2000",

issn = "1359-7345",

publisher = "ROYAL SOC CHEMISTRY",

number = "8",

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TY - JOUR

T1 - Distortion of a cellobio-derived isofagomine highlights the potential conformational itinerary of inverting β-glucosidases

AU - Varrot, A.

AU - Macdonald, J.

AU - Stick, Robert

AU - Pell, G.

AU - Gilbert, H.J.

AU - Davies, G.J.

PY - 2003

Y1 - 2003

N2 - A cellobio-derived isofagomine glycosidase inhibitor (Ki 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

AB - A cellobio-derived isofagomine glycosidase inhibitor (Ki 400 nM) displays an unusual distorted 2,5B (boat) conformation upon binding to cellobiohydrolase Cel6A from Humicola insolens, highlighting the different conformational itineraries used by various glycosidases, with consequences for the design of therapeutic agents.

M3 - Article

VL - 8

SP - 946

EP - 947

JO - Chemical Communications, 2000

JF - Chemical Communications, 2000

SN - 1359-7345

IS - 8

ER -