Distinct effects of testosterone on plasma and cerebrospinal fluid amyloid-b levels

E.J. Wahjoepramono, L.K. Wijaya, K. Taddei, G. Martins, M. Howard, K. De Ruyck, K. Bates, S.S. Dhaliwal, Giuseppe Verdile, M. Carruthers, Ralph Martins

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    22 Citations (Scopus)

    Abstract

    The effect of testosterone on the levels of the Alzheimer's disease amyloid-β peptide (Aβ) was investigated in guinea pigs. Castrated guinea pigs (GPX) were administered testosterone at two different dosages, following which plasma and cerebrospinal fluid (CSF) Aβ_{40} levels were measured. Plasma Aβ_{40} levels were reduced in GPX in the early stages of low-dose testosterone treatment, whereas CSF Aβ_{40} levels were only reduced by the time circulating testosterone had returned to untreated GPX levels. The supraphysiological testosterone dose did not reduce CSF Aβ_{40} levels significantly until circulating testosterone was back to uncastrated levels, whereas plasma Aβ_{40} levels significantly increased over time in these animals. These results indicate that the extent of testosterone-induced changes to Aβ_{40} levels and their response rates depend on both the tissue examined and testosterone dosage.
    Original languageEnglish
    Pages (from-to)129-137
    JournalJournal of Alzheimer's Disease
    Volume15
    Issue number1
    Publication statusPublished - 2008

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