Discovery of brevijanazines from Aspergillus brevijanus reveals the molecular basis for p-nitrobenzoic acid in fungi

Hang Li, Paul M. Mirzayans, Mark S. Butler, Alastair E. Lacey, Daniel Vuong, Rachel Chen, John A. Kalaitzis, Stephen A. Moggach, Ernest Lacey, Andrew M. Piggott, Yit Heng Chooi

Research output: Contribution to journalArticlepeer-review

Abstract

The brevijanazines are novel p-nitrobenzoylated piperazines isolated from Aspergillus brevijanus. Their structures were elucidated by spectroscopic analysis, X-ray crystallography and total synthesis. Heterologous biosynthesis, precursor feeding and in vitro microsomal assays unveiled the biosynthetic pathway to the brevijanazines, featuring a cytochrome P450 oxygenase that converts p-aminobenzoic acid to p-nitrobenzoic acid.

Original languageEnglish
Pages (from-to)6296-6299
Number of pages4
JournalChemical communications (Cambridge, England)
Volume58
Issue number43
DOIs
Publication statusPublished - 4 May 2022

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