Projects per year
Abstract
The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.
Original language | English |
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Pages (from-to) | 1287-1291 |
Number of pages | 5 |
Journal | Organic Letters |
Volume | 21 |
Issue number | 5 |
DOIs | |
Publication status | Published - 1 Mar 2019 |
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Dive into the research topics of 'Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii'. Together they form a unique fingerprint.Projects
- 1 Finished
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Uncovering the Hidden Secondary Metabolite Biosynthetic Potential of Fungi
1/01/17 → 15/03/21
Project: Research