Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii

Hang Li, Cameron L.M. Gilchrist, Heather J. Lacey, Andrew Crombie, Daniel Vuong, John I. Pitt, Ernest Lacey, Yit Heng Chooi, Andrew M. Piggott

Research output: Contribution to journalArticlepeer-review

37 Citations (Scopus)
94 Downloads (Pure)

Abstract

The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalOrganic Letters
Volume21
Issue number5
DOIs
Publication statusPublished - 1 Mar 2019

Fingerprint

Dive into the research topics of 'Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii'. Together they form a unique fingerprint.

Cite this