Abstract
The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.
| Original language | English |
|---|---|
| Pages (from-to) | 1287-1291 |
| Number of pages | 5 |
| Journal | Organic Letters |
| Volume | 21 |
| Issue number | 5 |
| DOIs | |
| Publication status | Published - 1 Mar 2019 |
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Discovery and Heterologous Biosynthesis of the Burnettramic Acids : Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii. / Li, Hang; Gilchrist, Cameron L.M.; Lacey, Heather J.; Crombie, Andrew; Vuong, Daniel; Pitt, John I.; Lacey, Ernest; Chooi, Yit Heng; Piggott, Andrew M.
In: Organic Letters, Vol. 21, No. 5, 01.03.2019, p. 1287-1291.Research output: Contribution to journal › Article
TY - JOUR
T1 - Discovery and Heterologous Biosynthesis of the Burnettramic Acids
T2 - Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii
AU - Li, Hang
AU - Gilchrist, Cameron L.M.
AU - Lacey, Heather J.
AU - Crombie, Andrew
AU - Vuong, Daniel
AU - Pitt, John I.
AU - Lacey, Ernest
AU - Chooi, Yit Heng
AU - Piggott, Andrew M.
PY - 2019/3/1
Y1 - 2019/3/1
N2 - The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.
AB - The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.
UR - http://www.scopus.com/inward/record.url?scp=85061545940&partnerID=8YFLogxK
U2 - 10.1021/acs.orglett.8b04042
DO - 10.1021/acs.orglett.8b04042
M3 - Article
VL - 21
SP - 1287
EP - 1291
JO - Organic Letters
JF - Organic Letters
SN - 1523-7052
IS - 5
ER -