Discovery and Heterologous Biosynthesis of the Burnettramic Acids: Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii

Hang Li, Cameron L.M. Gilchrist, Heather J. Lacey, Andrew Crombie, Daniel Vuong, John I. Pitt, Ernest Lacey, Yit Heng Chooi, Andrew M. Piggott

Research output: Contribution to journalArticle

Abstract

The burnettramic acids are a new class of antibiotics from an Australian fungus Aspergillus burnettii. The rare bolaamphiphilic scaffold consists of β-d-mannose linked to a pyrrolizidinedione unit via a 26-carbon chain. The most abundant metabolite displayed potent in vitro antifungal activity. Comparative genomics identified the hybrid PKS-NRPS bua gene cluster, which was verified by heterologous pathway reconstitution in Aspergillus nidulans.

Original languageEnglish
Pages (from-to)1287-1291
Number of pages5
JournalOrganic Letters
Volume21
Issue number5
DOIs
Publication statusPublished - 1 Mar 2019

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Aspergillus
Aspergillus nidulans
biosynthesis
fungi
Biosynthesis
Mannose
Multigene Family
Genomics
Fungi
Carbon
Anti-Bacterial Agents
acids
Acids
antibiotics
metabolites
Scaffolds (biology)
Metabolites
genes
Genes
carbon

Cite this

Li, Hang ; Gilchrist, Cameron L.M. ; Lacey, Heather J. ; Crombie, Andrew ; Vuong, Daniel ; Pitt, John I. ; Lacey, Ernest ; Chooi, Yit Heng ; Piggott, Andrew M. / Discovery and Heterologous Biosynthesis of the Burnettramic Acids : Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii. In: Organic Letters. 2019 ; Vol. 21, No. 5. pp. 1287-1291.
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Discovery and Heterologous Biosynthesis of the Burnettramic Acids : Rare PKS-NRPS-Derived Bolaamphiphilic Pyrrolizidinediones from an Australian Fungus, Aspergillus burnettii. / Li, Hang; Gilchrist, Cameron L.M.; Lacey, Heather J.; Crombie, Andrew; Vuong, Daniel; Pitt, John I.; Lacey, Ernest; Chooi, Yit Heng; Piggott, Andrew M.

In: Organic Letters, Vol. 21, No. 5, 01.03.2019, p. 1287-1291.

Research output: Contribution to journalArticle

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