Direct visualization of death of neurones projecting to specific targets in the developing rat brain

A. R. Harvey; D. Robertson; K. S. Cole

doi:10.1007/BF00228865

Direct visualization of death of neurones projecting to specific targets in the developing rat brain

A. R. Harvey, D. Robertson, K. S. Cole

Research output: Contribution to journal › Article › peer-review

13 Citations (Scopus)

Abstract

The fluorescent dye diamidino yellow was injected into parts of the developing visual and auditory systems in the rat. The dye was retrogradely transported by projecting neurones and was found to stain pyknotic profiles within the labelled cell populations. It is thus possible to visualize directly the death of neurones which project axons to specific and identified target regions within the nervous system.

Original language	English
Pages (from-to)	213-217
Number of pages	5
Journal	Experimental Brain Research
Volume	80
Issue number	1
DOIs	https://doi.org/10.1007/BF00228865
Publication status	Published - 1 Apr 1990

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title = "Direct visualization of death of neurones projecting to specific targets in the developing rat brain",

abstract = "The fluorescent dye diamidino yellow was injected into parts of the developing visual and auditory systems in the rat. The dye was retrogradely transported by projecting neurones and was found to stain pyknotic profiles within the labelled cell populations. It is thus possible to visualize directly the death of neurones which project axons to specific and identified target regions within the nervous system.",

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AB - The fluorescent dye diamidino yellow was injected into parts of the developing visual and auditory systems in the rat. The dye was retrogradely transported by projecting neurones and was found to stain pyknotic profiles within the labelled cell populations. It is thus possible to visualize directly the death of neurones which project axons to specific and identified target regions within the nervous system.

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KW - Developmental cell death

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KW - Retrograde transport

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Direct visualization of death of neurones projecting to specific targets in the developing rat brain

Abstract

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