Direct infant UV light exposure is associated with eczema and immune development

Kristina Rueter, Anderson Jones, Aris Siafarikas, Lim EM, Natasha Bear, Paul Noakes, Susan Prescott, Debra Palmer

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Background: Suboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes.Objective: We sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development.Methods: By using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age. Some infants also wore personal UV dosimeters to measure direct UV light (290-380 nm) exposure. Infant vitamin D levels were measured at 3 and 6 months of age. Eczema, wheeze, and immune function outcomes were assessed at 6 months of age.Results: At 3 (P < .01) and 6 (P = .02) months of age, vitamin D levels were greater for the vitamin D–supplemented group than the placebo group, but there was no difference in eczema incidence between groups. Infants with eczema were found to have had less UV light exposure (median, 555 Joules per square meter [J/m2; interquartile range, 322-1210 J/m2]) compared with those without eczema (median, 998 J/m2 [interquartile range, 676-1577 J/m2]; P = .02). UV light exposure was also inversely correlated with IL-2, GM-CSF, and eotaxin production to Toll-like receptor ligands.Conclusion: This study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema and proinflammatory immune markers by 6 months of age. Our findings indicate that UV light exposure appears more beneficial than vitamin D supplementation as an allergy prevention strategy in early life.
Original languageEnglish
Pages (from-to)1012-+
Number of pages11
JournalThe Journal of Allergy and Clinical Immunology
Volume143
Issue number3
DOIs
Publication statusPublished - Mar 2019

Fingerprint

Eczema
Ultraviolet Rays
Vitamin D
Placebos
Toll-Like Receptors
Incidence
Granulocyte-Macrophage Colony-Stimulating Factor
Vitamins
Interleukin-2
Hypersensitivity
Randomized Controlled Trials
Biomarkers
Newborn Infant
Ligands

Cite this

@article{2700939681c74a9ab1ee37336a816cd6,
title = "Direct infant UV light exposure is associated with eczema and immune development",
abstract = "Background: Suboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes.Objective: We sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development.Methods: By using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age. Some infants also wore personal UV dosimeters to measure direct UV light (290-380 nm) exposure. Infant vitamin D levels were measured at 3 and 6 months of age. Eczema, wheeze, and immune function outcomes were assessed at 6 months of age.Results: At 3 (P < .01) and 6 (P = .02) months of age, vitamin D levels were greater for the vitamin D–supplemented group than the placebo group, but there was no difference in eczema incidence between groups. Infants with eczema were found to have had less UV light exposure (median, 555 Joules per square meter [J/m2; interquartile range, 322-1210 J/m2]) compared with those without eczema (median, 998 J/m2 [interquartile range, 676-1577 J/m2]; P = .02). UV light exposure was also inversely correlated with IL-2, GM-CSF, and eotaxin production to Toll-like receptor ligands.Conclusion: This study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema and proinflammatory immune markers by 6 months of age. Our findings indicate that UV light exposure appears more beneficial than vitamin D supplementation as an allergy prevention strategy in early life.",
keywords = "allergy prevention",
author = "Kristina Rueter and Anderson Jones and Aris Siafarikas and Lim EM and Natasha Bear and Paul Noakes and Susan Prescott and Debra Palmer",
year = "2019",
month = "3",
doi = "10.1016/j.jaci.2018.08.037",
language = "English",
volume = "143",
pages = "1012--+",
journal = "The Journal of Allergy and Clinical Immunology",
issn = "0091-6749",
publisher = "Elsevier - Mosby",
number = "3",

}

Direct infant UV light exposure is associated with eczema and immune development. / Rueter, Kristina; Jones, Anderson; Siafarikas, Aris; EM, Lim; Bear, Natasha; Noakes, Paul; Prescott, Susan; Palmer, Debra.

In: The Journal of Allergy and Clinical Immunology, Vol. 143, No. 3, 03.2019, p. 1012-+.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Direct infant UV light exposure is associated with eczema and immune development

AU - Rueter, Kristina

AU - Jones, Anderson

AU - Siafarikas, Aris

AU - EM, Lim

AU - Bear, Natasha

AU - Noakes, Paul

AU - Prescott, Susan

AU - Palmer, Debra

PY - 2019/3

Y1 - 2019/3

N2 - Background: Suboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes.Objective: We sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development.Methods: By using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age. Some infants also wore personal UV dosimeters to measure direct UV light (290-380 nm) exposure. Infant vitamin D levels were measured at 3 and 6 months of age. Eczema, wheeze, and immune function outcomes were assessed at 6 months of age.Results: At 3 (P < .01) and 6 (P = .02) months of age, vitamin D levels were greater for the vitamin D–supplemented group than the placebo group, but there was no difference in eczema incidence between groups. Infants with eczema were found to have had less UV light exposure (median, 555 Joules per square meter [J/m2; interquartile range, 322-1210 J/m2]) compared with those without eczema (median, 998 J/m2 [interquartile range, 676-1577 J/m2]; P = .02). UV light exposure was also inversely correlated with IL-2, GM-CSF, and eotaxin production to Toll-like receptor ligands.Conclusion: This study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema and proinflammatory immune markers by 6 months of age. Our findings indicate that UV light exposure appears more beneficial than vitamin D supplementation as an allergy prevention strategy in early life.

AB - Background: Suboptimal vitamin D levels during critical periods of immune development have emerged as an explanation for higher rates of allergic diseases associated with industrialization and residing at higher latitudes.Objective: We sought to determine the effects of early postnatal vitamin D supplementation on infant eczema and immune development.Methods: By using a double-blind randomized controlled trial, newborn infants were randomized to receive vitamin D supplementation (400 IU/d) or a placebo until 6 months of age. Some infants also wore personal UV dosimeters to measure direct UV light (290-380 nm) exposure. Infant vitamin D levels were measured at 3 and 6 months of age. Eczema, wheeze, and immune function outcomes were assessed at 6 months of age.Results: At 3 (P < .01) and 6 (P = .02) months of age, vitamin D levels were greater for the vitamin D–supplemented group than the placebo group, but there was no difference in eczema incidence between groups. Infants with eczema were found to have had less UV light exposure (median, 555 Joules per square meter [J/m2; interquartile range, 322-1210 J/m2]) compared with those without eczema (median, 998 J/m2 [interquartile range, 676-1577 J/m2]; P = .02). UV light exposure was also inversely correlated with IL-2, GM-CSF, and eotaxin production to Toll-like receptor ligands.Conclusion: This study is the first to demonstrate an association between greater direct UV light exposures in early infancy with lower incidence of eczema and proinflammatory immune markers by 6 months of age. Our findings indicate that UV light exposure appears more beneficial than vitamin D supplementation as an allergy prevention strategy in early life.

KW - allergy prevention

U2 - 10.1016/j.jaci.2018.08.037

DO - 10.1016/j.jaci.2018.08.037

M3 - Article

VL - 143

SP - 1012-+

JO - The Journal of Allergy and Clinical Immunology

JF - The Journal of Allergy and Clinical Immunology

SN - 0091-6749

IS - 3

ER -