Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Joseph A. Ioppolo; Rikki A. Nezich; Kirsty L. Richardson; Laurence Morandeau; Peter J. Leedman; Roger I. Price

doi:10.1016/j.apradiso.2020.109164

Direct in vivo comparison of [¹⁸F]PSMA-1007 with [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Joseph A. Ioppolo, Rikki A. Nezich, Kirsty L. Richardson, Laurence Morandeau, Peter J. Leedman, Roger I. Price

Physics

Research output: Contribution to journal › Article › peer-review

12 Citations (Scopus)

Abstract

The aim of this preclinical study was to directly compare [¹⁸F]PSMA-1007 with both [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [¹⁸F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [¹⁸F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.

Original language	English
Article number	109164
Journal	Applied Radiation and Isotopes
Volume	161
DOIs	https://doi.org/10.1016/j.apradiso.2020.109164
Publication status	Published - Jul 2020

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title = "Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts",

abstract = "The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.",

keywords = "AlF-PSMA-11, Ga-PSMA-11, Preclinical, Prostate cancer, PSMA-1007",

author = "Ioppolo, {Joseph A.} and Nezich, {Rikki A.} and Richardson, {Kirsty L.} and Laurence Morandeau and Leedman, {Peter J.} and Price, {Roger I.}",

year = "2020",

month = jul,

doi = "10.1016/j.apradiso.2020.109164",

language = "English",

volume = "161",

journal = "Applied Radiation and Isotopes",

issn = "0969-8043",

publisher = "Elsevier",

}

TY - JOUR

T1 - Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

AU - Ioppolo, Joseph A.

AU - Nezich, Rikki A.

AU - Richardson, Kirsty L.

AU - Morandeau, Laurence

AU - Leedman, Peter J.

AU - Price, Roger I.

PY - 2020/7

Y1 - 2020/7

N2 - The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.

AB - The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.

KW - AlF-PSMA-11

KW - Ga-PSMA-11

KW - Preclinical

KW - Prostate cancer

KW - PSMA-1007

UR - http://www.scopus.com/inward/record.url?scp=85083030087&partnerID=8YFLogxK

U2 - 10.1016/j.apradiso.2020.109164

DO - 10.1016/j.apradiso.2020.109164

M3 - Article

C2 - 32321698

AN - SCOPUS:85083030087

SN - 0969-8043

VL - 161

JO - Applied Radiation and Isotopes

JF - Applied Radiation and Isotopes

M1 - 109164

ER -

Direct in vivo comparison of [¹⁸F]PSMA-1007 with [⁶⁸Ga]Ga-PSMA-11 and [¹⁸F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Abstract

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