Direct in vivo comparison of [18F]PSMA-1007 with [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-expressing xenografts

Joseph A. Ioppolo, Rikki A. Nezich, Kirsty L. Richardson, Laurence Morandeau, Peter J. Leedman, Roger I. Price

Research output: Contribution to journalArticle

Abstract

The aim of this preclinical study was to directly compare [18F]PSMA-1007 with both [68Ga]Ga-PSMA-11 and [18F]AlF-PSMA-11 in mice bearing PSMA-positive tumor xenografts. Uptake was assessed by PET/CT at 1, 2 and 4 h post-injection, and by ex vivo measurement after 4 h. [18F]PSMA-1007 demonstrated the highest tumor uptake of the three tracers. The high uptake in bone for mice injected with [18F]AlF-PSMA-11 suggested rapid in vivo decomposition. This was confirmed by an in vitro plasma stability study.

Original languageEnglish
Article number109164
JournalApplied Radiation and Isotopes
Volume161
DOIs
Publication statusPublished - Jul 2020

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