Direct evidence that inflammatory multinucleate giant cells form by fusion

A. R. Murch; Miranda D. Grounds; C. A. Marshall; J. M. Papadimitriou

doi:10.1002/path.1711370302

Direct evidence that inflammatory multinucleate giant cells form by fusion

A. R. Murch, Miranda D. Grounds, C. A. Marshall, J. M. Papadimitriou

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Abstract

Multinucleate giant cells (MGC) are believed to be formed by fusion of macrophages. In a chimaeric mouse composed of two histoincompatible strains each homozygous for one of the two isoenzymic forms of glucose‐6‐phosphate isomerase it was found that hybrid enzyme was produced in MGC‐rich leucocytic exudates. This hybrid can only occur if nuclei of the two different strains reside within a common syncytial cytoplasm, demonstrating unequivocally that macrophage fusion occurred between cells of the two strains. Since the two strains were histoincompatible it appears that no strain specific recognition is necessary for fusion to occur.

Original language	English
Pages (from-to)	177-180
Number of pages	4
Journal	The Journal of Pathology
Volume	137
Issue number	3
DOIs	https://doi.org/10.1002/path.1711370302
Publication status	Published - Jul 1982

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AU - Marshall, C. A.

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Direct evidence that inflammatory multinucleate giant cells form by fusion

Abstract

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