Direct effect of angiotensin II on in-vitro perfused rabbit ovary

T. C. Kuo, K. Endo, A. M. Dharmarajan, T. Miyazaki, S. J. Atlas, E. E. Wallach

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59 Citations (Scopus)


The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

Original languageEnglish
Pages (from-to)469-474
Number of pages6
JournalJournal of Reproduction and Fertility
Issue number2
Publication statusPublished - 1991
Externally publishedYes


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