Direct effect of angiotensin II on in-vitro perfused rabbit ovary

T. C. Kuo; K. Endo; A. M. Dharmarajan; T. Miyazaki; S. J. Atlas; E. E. Wallach

doi:10.1530/jrf.0.0920469

Direct effect of angiotensin II on in-vitro perfused rabbit ovary

T. C. Kuo, K. Endo, A. M. Dharmarajan, T. Miyazaki, S. J. Atlas, E. E. Wallach

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Abstract

The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

Original language	English
Pages (from-to)	469-474
Number of pages	6
Journal	Journal of Reproduction and Fertility
Volume	92
Issue number	2
DOIs	https://doi.org/10.1530/jrf.0.0920469
Publication status	Published - 1991
Externally published	Yes

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title = "Direct effect of angiotensin II on in-vitro perfused rabbit ovary",

abstract = "The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.",

keywords = "Angiotensin II, Oocyte maturation, Ovary, Ovulation, Rabbit, Saralasin",

author = "Kuo, {T. C.} and K. Endo and Dharmarajan, {A. M.} and T. Miyazaki and Atlas, {S. J.} and Wallach, {E. E.}",

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doi = "10.1530/jrf.0.0920469",

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pages = "469--474",

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T1 - Direct effect of angiotensin II on in-vitro perfused rabbit ovary

AU - Kuo, T. C.

AU - Endo, K.

AU - Dharmarajan, A. M.

AU - Miyazaki, T.

AU - Atlas, S. J.

AU - Wallach, E. E.

PY - 1991

Y1 - 1991

N2 - The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

AB - The effects of angiotensin II (AII) and its receptor blocker, saralasin (SAR), on ovulation and oocyte maturation were investigated in an isolated, in-vitro perfused rabbit ovary. Ovulation and oocyte maturation were induced by AII in the absence of human chorionic gonadotrophin (hCG). SAR inhibited ovulation induced by AII or hCG, but not oocyte maturation. AII appears to play a critical role in follicle rupture, but not in resumption of oocyte meiosis.

KW - Angiotensin II

KW - Oocyte maturation

KW - Ovary

KW - Ovulation

KW - Rabbit

KW - Saralasin

UR - http://www.scopus.com/inward/record.url?scp=0025773772&partnerID=8YFLogxK

U2 - 10.1530/jrf.0.0920469

DO - 10.1530/jrf.0.0920469

M3 - Article

C2 - 1886102

AN - SCOPUS:0025773772

SN - 0022-4251

VL - 92

SP - 469

EP - 474

JO - Journal of Reproduction and Fertility

JF - Journal of Reproduction and Fertility

IS - 2

ER -

Direct effect of angiotensin II on in-vitro perfused rabbit ovary

Abstract

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