Projects per year
© 2016 The Royal Society of Chemistry. We have synthesized a new series of azolium cyclophanes and used them as precursors of inherently luminescent dinuclear Au(i)-N-heterocyclic carbene (NHC) complexes. The azolium cyclophanes contained two azolium groups (either imidazolium or benzimidazolium), an o-xylyl group, and an alkyl linker chain (either C2, C3 or C4). All of the azolium cyclophanes were characterised by X-ray diffraction studies and VT NMR studies, and all were fluxional in solution on the NMR timescale. The C3- and C4-linked azolium cyclophanes served as precursors of Au2L22+ complexes (L is a cyclophane bis(NHC) ligand). Due to the unsymmetrical nature of the azolium cyclophanes, the Au2L22+ complexes each existed as cis and trans isomers. X-ray diffraction studies showed that the Au2L22+ complexes had short intramolecular Au?Au distances, in the range 2.9-3.3 Å, suggestive of an aurophilic attraction, presumably as a consequence of the geometrical constraints imposed by the cyclophane bis(NHC) ligands. The complexes having the shortest Au?Au distances (i.e., those based on C3-linked cyclophanes) exhibited intense luminescence in solution. The uptake of one of the dinuclear Au-NHC complexes by tumorigenic cells, and its subsequent distribution and toxicity in the cells, was monitored by luminescence microscopy over 6 h and proliferation measurements, respectively.
|Journal||Dalton Transactions: the international journal for inorganic, organometallic and bioinorganic chemistry|
|Early online date||6 Jul 2016|
|Publication status||Published - 14 Aug 2016|
Gold Phosphine and Carbene Complexes as Potential Antimitochondrial Anticancer Agents: Design, Synthesis and Biological Chemistry.
Berners-Price, S. & Baker, M.
1/01/04 → 31/12/06