Differential effects of physostigmine on cues produced by electrical stimulation of the ventral tegmental area using two discrimination procedures

J. P. Druhan, M. T. Martin-Iverson, D. M. Wilkie, H. C. Fibiger, A. G. Phillips

Research output: Contribution to journalArticle

5 Citations (Scopus)


Two procedures were employed to assess the effects of physostigmine on the discrimination of cues produced by either high or low intensity electrical brain stimulation (EBS) of the ventral tegmental area in rats. When the procedure involved frequent presentation of brief trials, physostigmine enhanced the perceived intensities of the cues, causing the rats to respond to low intensities as though they had higher values. In contrast, physostigmine had no effects on the discrimination when the trials were less frequent and extended in duration. These results confirm the existence of multiple substrates for cues produced by stimulation of the ventral tegmental area in rats and implicate cholinergic neurons as substrates for the non-dopaminergic cues indentified in the companion paper.

Original languageEnglish
Pages (from-to)261-265
Number of pages5
JournalPharmacology, Biochemistry and Behavior
Issue number2
Publication statusPublished - 1 Jan 1987
Externally publishedYes


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