Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men

Simon Carrivick, Helman Alfonso, Jonathan Golledge, Paula Clancy, Leon Flicker, Jenny E Gunton, Graeme J Hankey, Osvaldo P Almeida, Paul E Norman, Bu B Yeap

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Abstract

AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.

METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.

RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95% CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.

CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.

Original languageEnglish
Pages (from-to)e3172
JournalDiabetes/Metabolism Research and Reviews
DOIs
Publication statusE-pub ahead of print - 10 Jun 2019

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Independent Living
Ferritins
Fasting
Glucose
Vitamin D
Western Australia
Self Report
25-hydroxyvitamin D
Cross-Sectional Studies
Demography
Clinical Trials
Incidence

Cite this

@article{1cc1a0ccf87540e1bafc52e8b95e4402,
title = "Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men",
abstract = "AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.RESULTS: There were 577 men with diabetes (13.9{\%}). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95{\%} confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95{\%} CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.",
author = "Simon Carrivick and Helman Alfonso and Jonathan Golledge and Paula Clancy and Leon Flicker and Gunton, {Jenny E} and Hankey, {Graeme J} and Almeida, {Osvaldo P} and Norman, {Paul E} and Yeap, {Bu B}",
year = "2019",
month = "6",
day = "10",
doi = "10.1002/dmrr.3172",
language = "English",
pages = "e3172",
journal = "Diabetes/Metabolism Research and Reviews",
issn = "1520-7552",
publisher = "John Wiley & Sons",

}

TY - JOUR

T1 - Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men

AU - Carrivick, Simon

AU - Alfonso, Helman

AU - Golledge, Jonathan

AU - Clancy, Paula

AU - Flicker, Leon

AU - Gunton, Jenny E

AU - Hankey, Graeme J

AU - Almeida, Osvaldo P

AU - Norman, Paul E

AU - Yeap, Bu B

PY - 2019/6/10

Y1 - 2019/6/10

N2 - AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95% CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.

AB - AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95% CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.

U2 - 10.1002/dmrr.3172

DO - 10.1002/dmrr.3172

M3 - Article

SP - e3172

JO - Diabetes/Metabolism Research and Reviews

JF - Diabetes/Metabolism Research and Reviews

SN - 1520-7552

ER -