Abstract
AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.
METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.
RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95% CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.
CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.
| Original language | English |
|---|---|
| Pages (from-to) | e3172 |
| Journal | Diabetes/Metabolism Research and Reviews |
| DOIs | |
| Publication status | E-pub ahead of print - 10 Jun 2019 |
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Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men. / Carrivick, Simon; Alfonso, Helman; Golledge, Jonathan; Clancy, Paula; Flicker, Leon; Gunton, Jenny E; Hankey, Graeme J; Almeida, Osvaldo P; Norman, Paul E; Yeap, Bu B.
In: Diabetes/Metabolism Research and Reviews, 10.06.2019, p. e3172.Research output: Contribution to journal › Article
TY - JOUR
T1 - Differential associations of ferritin and 25-hydroxyvitamin D with fasting glucose and diabetes risk in community dwelling older men
AU - Carrivick, Simon
AU - Alfonso, Helman
AU - Golledge, Jonathan
AU - Clancy, Paula
AU - Flicker, Leon
AU - Gunton, Jenny E
AU - Hankey, Graeme J
AU - Almeida, Osvaldo P
AU - Norman, Paul E
AU - Yeap, Bu B
PY - 2019/6/10
Y1 - 2019/6/10
N2 - AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95% CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.
AB - AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95% CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.
U2 - 10.1002/dmrr.3172
DO - 10.1002/dmrr.3172
M3 - Article
SP - e3172
JO - Diabetes/Metabolism Research and Reviews
JF - Diabetes/Metabolism Research and Reviews
SN - 1520-7552
ER -