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Abstract
AIMS: We examined associations of ferritin and 25-hydroxyvitamin D with fasting glucose and prevalent diabetes in older men.
METHODS: Cross-sectional analysis of 4,153 community-dwelling men aged 70-89 years in Western Australia. Plasma ferritin, 25-hydroxyvitamin D and glucose were assayed. Diabetes was ascertained from self-report, medications and fasting glucose.
RESULTS: There were 577 men with diabetes (13.9%). In the whole cohort, ferritin was associated with fasting glucose (0.051 mmol/L per 1SD increase in ferritin, p=0.006) and 25-hydroxyvitamin D was inversely associated (-0.085 mmol/L per 1SD, p<0.001). Ferritin was not associated with prevalent diabetes (highest vs. lowest quartile; >225 vs <66 μg/L: adjusted odds ratio [OR] 0.97, 95% confidence interval [CI], 0.74-1.27, p=0.83). Higher vitamin D was associated with decreased odds of prevalent diabetes (highest vs lowest quartile; >82 nmol/L vs <53 nmol/L: OR=0.57, 95% CI=0.43-0.75, p<0.001). There was no interaction between ferritin and vitamin D on diabetes risk.
CONCLUSIONS: In older men, ferritin is associated with fasting glucose but not prevalent diabetes. Higher 25-hydroxyvitamin D concentrations are independently associated with lower fasting glucose and reduced risk of diabetes. Clinical trials are required to determine whether interventions which raise vitamin D concentrations would reduce incidence of diabetes in this expanding demographic group.
Original language | English |
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Article number | e3172 |
Journal | Diabetes/Metabolism Research and Reviews |
Volume | 35 |
Issue number | 7 |
Early online date | 10 Jun 2019 |
DOIs | |
Publication status | Published - Oct 2019 |
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- 5 Finished
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Trajectories of circulating testosterone and estradiol and implications for the health of ageing men
Yeap, B., Flicker, L. & McCaul, K.
National Health & Medical Research Council NHMRC
1/01/14 → 30/06/16
Project: Research
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Successful Ageing in Older Men - Thriving Not Just Surviving in the Health In Men Study
Flicker, L., Almeida, O., Norman, P., Yeap, B. & McCaul, K.
National Health & Medical Research Council NHMRC
1/01/13 → 31/12/15
Project: Research
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Predicting Health & Disease in Australian Men Over the Age of 80 Years - the Health in Men Study
Flicker, L., Almeida, O., Hankey, G. & McCaul, K.
National Health & Medical Research Council NHMRC
1/01/10 → 31/12/12
Project: Research