Differential airway epithelial responses to rhinovirus species in children with acute wheeze and asthma

Rebecca Watkinson

doi:10.26182/eew5-8s80

Differential airway epithelial responses to rhinovirus species in children with acute wheeze and asthma

Rebecca Watkinson

UWA Medical School

Research output: Thesis › Doctoral Thesis

91 Downloads (Pure)

Abstract

Rhinovirus C (RV-C), is the most common virus in children with acute wheeze, is associated with
increased exacerbation severity, and shorter time to recurrence. This suggests a dysregulated airway
innate immune response to infection. Previously, investigating the airway epithelium of exacerbating
children was unattainable. Here, a differentiated nasal epithelial cell model of paediatric acute
wheeze and asthma (AWA) was established and identified vulnerabilities including dampened and
exaggerated RANTES release with RV-C and RV-A infection respectively. This thesis contributes to
the field through establishment of a platform to study AWA, and highlighting epithelial responses to
infection that can be therapeutically targeted

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Kicic, Anthony, Supervisor Laing, Ingrid, Supervisor Looi, Kevin, Supervisor Le Souef, Peter, Supervisor Iosifidis, Thomas, Supervisor
Thesis sponsors	Australian Government Research Training Program
Award date	1 Oct 2024
DOIs	https://doi.org/10.26182/eew5-8s80
Publication status	Unpublished - 2024

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10.26182/eew5-8s80

THESIS - DOCTOR OF PHILOSOPHY - WATKINSON Rebecca Louise - 2024_
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1 Review article

Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis
Watkinson, R. L., Looi, K., Laing, I. A., Cianferoni, A. & Kicic, A., 29 Nov 2021, In: Frontiers in Immunology. 12, 773600.
Research output: Contribution to journal › Review article › peer-review

Open Access
7 Citations (Scopus)

Cite this

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title = "Differential airway epithelial responses to rhinovirus species in children with acute wheeze and asthma",

abstract = "Rhinovirus C (RV-C), is the most common virus in children with acute wheeze, is associated withincreased exacerbation severity, and shorter time to recurrence. This suggests a dysregulated airwayinnate immune response to infection. Previously, investigating the airway epithelium of exacerbatingchildren was unattainable. Here, a differentiated nasal epithelial cell model of paediatric acutewheeze and asthma (AWA) was established and identified vulnerabilities including dampened andexaggerated RANTES release with RV-C and RV-A infection respectively. This thesis contributes tothe field through establishment of a platform to study AWA, and highlighting epithelial responses toinfection that can be therapeutically targeted",

keywords = "Asthma, Epithelium, Paediatric, Rhinovirus, Wheeze, RV-C, RV-A, Model",

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doi = "10.26182/eew5-8s80",

language = "English",

school = "The University of Western Australia",

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AU - Watkinson, Rebecca

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N2 - Rhinovirus C (RV-C), is the most common virus in children with acute wheeze, is associated withincreased exacerbation severity, and shorter time to recurrence. This suggests a dysregulated airwayinnate immune response to infection. Previously, investigating the airway epithelium of exacerbatingchildren was unattainable. Here, a differentiated nasal epithelial cell model of paediatric acutewheeze and asthma (AWA) was established and identified vulnerabilities including dampened andexaggerated RANTES release with RV-C and RV-A infection respectively. This thesis contributes tothe field through establishment of a platform to study AWA, and highlighting epithelial responses toinfection that can be therapeutically targeted

AB - Rhinovirus C (RV-C), is the most common virus in children with acute wheeze, is associated withincreased exacerbation severity, and shorter time to recurrence. This suggests a dysregulated airwayinnate immune response to infection. Previously, investigating the airway epithelium of exacerbatingchildren was unattainable. Here, a differentiated nasal epithelial cell model of paediatric acutewheeze and asthma (AWA) was established and identified vulnerabilities including dampened andexaggerated RANTES release with RV-C and RV-A infection respectively. This thesis contributes tothe field through establishment of a platform to study AWA, and highlighting epithelial responses toinfection that can be therapeutically targeted

KW - Asthma

KW - Epithelium

KW - Paediatric

KW - Rhinovirus

KW - Wheeze

KW - RV-C

KW - RV-A

KW - Model

U2 - 10.26182/eew5-8s80

DO - 10.26182/eew5-8s80

M3 - Doctoral Thesis

ER -

Differential airway epithelial responses to rhinovirus species in children with acute wheeze and asthma

Abstract

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Research output

Viral Induced Effects on a Vulnerable Epithelium; Lessons Learned From Paediatric Asthma and Eosinophilic Oesophagitis

Cite this