Differences in blood pressure in infants after general anesthesia compared to awake regional anesthesia (GAS Study-A Prospective Randomized Trial)

M. E. McCann; D. E. Withington; S. J. Arnup; A. J. Davidson; N. Disma; G. Frawley; N. S. Morton; G. Bell; R. W. Hunt; D. C. Bellinger; D. M. Polaner; A. Leo; A. R. Absalom; B. S. von Ungern-Sternberg; F. Izzo; P. Szmuk; V. Young; S. G. Soriano; J. C. de Graaff

doi:10.1213/ANE.0000000000001870

Differences in blood pressure in infants after general anesthesia compared to awake regional anesthesia (GAS Study-A Prospective Randomized Trial)

M. E. McCann, D. E. Withington, S. J. Arnup, A. J. Davidson, N. Disma, G. Frawley, N. S. Morton, G. Bell, R. W. Hunt, D. C. Bellinger, D. M. Polaner, A. Leo, A. R. Absalom, B. S. von Ungern-Sternberg, F. Izzo, P. Szmuk, V. Young, S. G. Soriano, J. C. de Graaff

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Abstract

BACKGROUND: The General Anesthesia compared to Spinal anesthesia (GAS) study is a prospective randomized, controlled, multisite, trial designed to assess the influence of general anesthesia (GA) on neurodevelopment at 5 years of age. A secondary aim obtained from the blood pressure data of the GAS trial is to compare rates of intraoperative hypotension after anesthesia and to identify risk factors for intraoperative hypotension.

METHODS: A total of 722 infants

RESULTS: The relative risk of GA compared with RA predicting any measured hypotension of

CONCLUSIONS: RA reduces the incidence of hypotension and the chance of intervention to treat it compared with sevoflurane anesthesia in young infants undergoing inguinal hernia repair.

Original language	English
Pages (from-to)	837-845
Number of pages	9
Journal	Anesthesia and Analgesia
Volume	125
Issue number	3
DOIs	https://doi.org/10.1213/ANE.0000000000001870
Publication status	Published - Sep 2017

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McCann, M. E., Withington, D. E., Arnup, S. J., Davidson, A. J., Disma, N., Frawley, G., Morton, N. S., Bell, G., Hunt, R. W., Bellinger, D. C., Polaner, D. M., Leo, A., Absalom, A. R., von Ungern-Sternberg, B. S., Izzo, F., Szmuk, P., Young, V., Soriano, S. G., & de Graaff, J. C. (2017). Differences in blood pressure in infants after general anesthesia compared to awake regional anesthesia (GAS Study-A Prospective Randomized Trial). Anesthesia and Analgesia, 125(3), 837-845. https://doi.org/10.1213/ANE.0000000000001870

@article{b1cad52026904b28bba9e51bb06943e1,

title = "Differences in blood pressure in infants after general anesthesia compared to awake regional anesthesia (GAS Study-A Prospective Randomized Trial)",

abstract = "BACKGROUND: The General Anesthesia compared to Spinal anesthesia (GAS) study is a prospective randomized, controlled, multisite, trial designed to assess the influence of general anesthesia (GA) on neurodevelopment at 5 years of age. A secondary aim obtained from the blood pressure data of the GAS trial is to compare rates of intraoperative hypotension after anesthesia and to identify risk factors for intraoperative hypotension.METHODS: A total of 722 infantsRESULTS: The relative risk of GA compared with RA predicting any measured hypotension ofCONCLUSIONS: RA reduces the incidence of hypotension and the chance of intervention to treat it compared with sevoflurane anesthesia in young infants undergoing inguinal hernia repair.",

keywords = "BIRTH-WEIGHT INFANTS, SEVOFLURANE ANESTHESIA, CHILDHOOD EXPOSURE, FLOW, CHILDREN, ARM, SURGERY, COHORT, BRAIN, LIFE",

author = "McCann, {M. E.} and Withington, {D. E.} and Arnup, {S. J.} and Davidson, {A. J.} and N. Disma and G. Frawley and Morton, {N. S.} and G. Bell and Hunt, {R. W.} and Bellinger, {D. C.} and Polaner, {D. M.} and A. Leo and Absalom, {A. R.} and {von Ungern-Sternberg}, {B. S.} and F. Izzo and P. Szmuk and V. Young and Soriano, {S. G.} and {de Graaff}, {J. C.}",

year = "2017",

month = sep,

doi = "10.1213/ANE.0000000000001870",

language = "English",

volume = "125",

pages = "837--845",

journal = "Anesthesia & analgesia",

issn = "0003-2999",

publisher = "Lippincott Williams & Wilkins",

number = "3",

}

McCann, ME, Withington, DE, Arnup, SJ, Davidson, AJ, Disma, N, Frawley, G, Morton, NS, Bell, G, Hunt, RW, Bellinger, DC, Polaner, DM, Leo, A, Absalom, AR, von Ungern-Sternberg, BS, Izzo, F, Szmuk, P, Young, V, Soriano, SG & de Graaff, JC 2017, 'Differences in blood pressure in infants after general anesthesia compared to awake regional anesthesia (GAS Study-A Prospective Randomized Trial)', Anesthesia and Analgesia, vol. 125, no. 3, pp. 837-845. https://doi.org/10.1213/ANE.0000000000001870

TY - JOUR

T1 - Differences in blood pressure in infants after general anesthesia compared to awake regional anesthesia (GAS Study-A Prospective Randomized Trial)

AU - McCann, M. E.

AU - Withington, D. E.

AU - Arnup, S. J.

AU - Davidson, A. J.

AU - Disma, N.

AU - Frawley, G.

AU - Morton, N. S.

AU - Bell, G.

AU - Hunt, R. W.

AU - Bellinger, D. C.

AU - Polaner, D. M.

AU - Leo, A.

AU - Absalom, A. R.

AU - von Ungern-Sternberg, B. S.

AU - Izzo, F.

AU - Szmuk, P.

AU - Young, V.

AU - Soriano, S. G.

AU - de Graaff, J. C.

PY - 2017/9

Y1 - 2017/9

N2 - BACKGROUND: The General Anesthesia compared to Spinal anesthesia (GAS) study is a prospective randomized, controlled, multisite, trial designed to assess the influence of general anesthesia (GA) on neurodevelopment at 5 years of age. A secondary aim obtained from the blood pressure data of the GAS trial is to compare rates of intraoperative hypotension after anesthesia and to identify risk factors for intraoperative hypotension.METHODS: A total of 722 infantsRESULTS: The relative risk of GA compared with RA predicting any measured hypotension ofCONCLUSIONS: RA reduces the incidence of hypotension and the chance of intervention to treat it compared with sevoflurane anesthesia in young infants undergoing inguinal hernia repair.

AB - BACKGROUND: The General Anesthesia compared to Spinal anesthesia (GAS) study is a prospective randomized, controlled, multisite, trial designed to assess the influence of general anesthesia (GA) on neurodevelopment at 5 years of age. A secondary aim obtained from the blood pressure data of the GAS trial is to compare rates of intraoperative hypotension after anesthesia and to identify risk factors for intraoperative hypotension.METHODS: A total of 722 infantsRESULTS: The relative risk of GA compared with RA predicting any measured hypotension ofCONCLUSIONS: RA reduces the incidence of hypotension and the chance of intervention to treat it compared with sevoflurane anesthesia in young infants undergoing inguinal hernia repair.

KW - BIRTH-WEIGHT INFANTS

KW - SEVOFLURANE ANESTHESIA

KW - CHILDHOOD EXPOSURE

KW - FLOW

KW - CHILDREN

KW - ARM

KW - SURGERY

KW - COHORT

KW - BRAIN

KW - LIFE

U2 - 10.1213/ANE.0000000000001870

DO - 10.1213/ANE.0000000000001870

M3 - Article

C2 - 28489641

VL - 125

SP - 837

EP - 845

JO - Anesthesia & analgesia

JF - Anesthesia & analgesia

SN - 0003-2999

IS - 3

ER -

Differences in blood pressure in infants after general anesthesia compared to awake regional anesthesia (GAS Study-A Prospective Randomized Trial)

Abstract

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