Dietary prevention of allergic diseases in infants and small children. Part 1: Immunologic background and criteria for hypoallergenicity

A. Muraro; S. Dreborg; S. Halken; A. Host; B. Niggemann; R. Aalberse; S.H. Arshad; A. Von Berg; K-H. Kon Carlsen; K. Duschen; P. Eigenmann; D. Hill; C. Jones; M. Mellon; G. Oldeus; A. Oranje; C. Pascual; Susan Prescott; H. Sampson; M. Svartengren; Y. Vandenplas; U. Wahn; J.A. Warner; J.O. Warner; M. Wickman; R.S. Zeiger

doi:10.1046/j.1399-3038.2003.00129.x

Dietary prevention of allergic diseases in infants and small children. Part 1: Immunologic background and criteria for hypoallergenicity

A. Muraro, S. Dreborg, S. Halken, A. Host, B. Niggemann, R. Aalberse, S.H. Arshad, A. Von Berg, K-H. Kon Carlsen, K. Duschen, P. Eigenmann, D. Hill, C. Jones, M. Mellon, G. Oldeus, A. Oranje, C. Pascual, Susan Prescott, H. Sampson, M. SvartengrenY. Vandenplas, U. Wahn, J.A. Warner, J.O. Warner, M. Wickman, R.S. Zeiger

Graduate Research School

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Abstract

The role of primary prevention of allergic diseases has been a matter ofdebate for the last 40 years. In order to shed some light into this issue, agroup of experts of the Section of Pediatrics EAACI critically reviewedthe existing literature on the subject. In this paper, the immunology ofthe fetus and newborn is reviewed as well as the post-natal developmentof the immune system. The influence of post-natal environment andbreastfeeding on tolerance induction and sensitization are examined.Allergic diseases result from a strong relationship between genetic andenvironmental factors. Sensitization to food allergens occurs in the firstyear of life and cow’s milk allergy is the first food allergy to appear inthe susceptible infants. Hypoallergenicity of food formulas to be used isa critical issue both for treatment of cow’s milk-allergic children and forprevention. Methods to document hypoallergenicity are discussed andevaluated in the preclinical and clinical steps.

Original language	English
Pages (from-to)	103-111
Journal	Pediatric Allergy and Immunology
Volume	15
Issue number	2
DOIs	https://doi.org/10.1046/j.1399-3038.2003.00129.x
Publication status	Published - 2004

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Muraro, A., Dreborg, S., Halken, S., Host, A., Niggemann, B., Aalberse, R., Arshad, S. H., Von Berg, A., Kon Carlsen, K.-H., Duschen, K., Eigenmann, P., Hill, D., Jones, C., Mellon, M., Oldeus, G., Oranje, A., Pascual, C., Prescott, S., Sampson, H., ... Zeiger, R. S. (2004). Dietary prevention of allergic diseases in infants and small children. Part 1: Immunologic background and criteria for hypoallergenicity. Pediatric Allergy and Immunology, 15(2), 103-111. https://doi.org/10.1046/j.1399-3038.2003.00129.x

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title = "Dietary prevention of allergic diseases in infants and small children. Part 1: Immunologic background and criteria for hypoallergenicity",

abstract = "The role of primary prevention of allergic diseases has been a matter ofdebate for the last 40 years. In order to shed some light into this issue, agroup of experts of the Section of Pediatrics EAACI critically reviewedthe existing literature on the subject. In this paper, the immunology ofthe fetus and newborn is reviewed as well as the post-natal developmentof the immune system. The influence of post-natal environment andbreastfeeding on tolerance induction and sensitization are examined.Allergic diseases result from a strong relationship between genetic andenvironmental factors. Sensitization to food allergens occurs in the firstyear of life and cow{\textquoteright}s milk allergy is the first food allergy to appear inthe susceptible infants. Hypoallergenicity of food formulas to be used isa critical issue both for treatment of cow{\textquoteright}s milk-allergic children and forprevention. Methods to document hypoallergenicity are discussed andevaluated in the preclinical and clinical steps.",

author = "A. Muraro and S. Dreborg and S. Halken and A. Host and B. Niggemann and R. Aalberse and S.H. Arshad and {Von Berg}, A. and {Kon Carlsen}, K-H. and K. Duschen and P. Eigenmann and D. Hill and C. Jones and M. Mellon and G. Oldeus and A. Oranje and C. Pascual and Susan Prescott and H. Sampson and M. Svartengren and Y. Vandenplas and U. Wahn and J.A. Warner and J.O. Warner and M. Wickman and R.S. Zeiger",

year = "2004",

doi = "10.1046/j.1399-3038.2003.00129.x",

language = "English",

volume = "15",

pages = "103--111",

journal = "Pediatric Allergy and Immunology",

issn = "0905-6157",

publisher = "Blackwell",

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Muraro, A, Dreborg, S, Halken, S, Host, A, Niggemann, B, Aalberse, R, Arshad, SH, Von Berg, A, Kon Carlsen, K-H, Duschen, K, Eigenmann, P, Hill, D, Jones, C, Mellon, M, Oldeus, G, Oranje, A, Pascual, C, Prescott, S, Sampson, H, Svartengren, M, Vandenplas, Y, Wahn, U, Warner, JA, Warner, JO, Wickman, M & Zeiger, RS 2004, 'Dietary prevention of allergic diseases in infants and small children. Part 1: Immunologic background and criteria for hypoallergenicity', Pediatric Allergy and Immunology, vol. 15, no. 2, pp. 103-111. https://doi.org/10.1046/j.1399-3038.2003.00129.x

TY - JOUR

T1 - Dietary prevention of allergic diseases in infants and small children. Part 1: Immunologic background and criteria for hypoallergenicity

AU - Muraro, A.

AU - Dreborg, S.

AU - Halken, S.

AU - Host, A.

AU - Niggemann, B.

AU - Aalberse, R.

AU - Arshad, S.H.

AU - Von Berg, A.

AU - Kon Carlsen, K-H.

AU - Duschen, K.

AU - Eigenmann, P.

AU - Hill, D.

AU - Jones, C.

AU - Mellon, M.

AU - Oldeus, G.

AU - Oranje, A.

AU - Pascual, C.

AU - Prescott, Susan

AU - Sampson, H.

AU - Svartengren, M.

AU - Vandenplas, Y.

AU - Wahn, U.

AU - Warner, J.A.

AU - Warner, J.O.

AU - Wickman, M.

AU - Zeiger, R.S.

PY - 2004

Y1 - 2004

N2 - The role of primary prevention of allergic diseases has been a matter ofdebate for the last 40 years. In order to shed some light into this issue, agroup of experts of the Section of Pediatrics EAACI critically reviewedthe existing literature on the subject. In this paper, the immunology ofthe fetus and newborn is reviewed as well as the post-natal developmentof the immune system. The influence of post-natal environment andbreastfeeding on tolerance induction and sensitization are examined.Allergic diseases result from a strong relationship between genetic andenvironmental factors. Sensitization to food allergens occurs in the firstyear of life and cow’s milk allergy is the first food allergy to appear inthe susceptible infants. Hypoallergenicity of food formulas to be used isa critical issue both for treatment of cow’s milk-allergic children and forprevention. Methods to document hypoallergenicity are discussed andevaluated in the preclinical and clinical steps.

AB - The role of primary prevention of allergic diseases has been a matter ofdebate for the last 40 years. In order to shed some light into this issue, agroup of experts of the Section of Pediatrics EAACI critically reviewedthe existing literature on the subject. In this paper, the immunology ofthe fetus and newborn is reviewed as well as the post-natal developmentof the immune system. The influence of post-natal environment andbreastfeeding on tolerance induction and sensitization are examined.Allergic diseases result from a strong relationship between genetic andenvironmental factors. Sensitization to food allergens occurs in the firstyear of life and cow’s milk allergy is the first food allergy to appear inthe susceptible infants. Hypoallergenicity of food formulas to be used isa critical issue both for treatment of cow’s milk-allergic children and forprevention. Methods to document hypoallergenicity are discussed andevaluated in the preclinical and clinical steps.

U2 - 10.1046/j.1399-3038.2003.00129.x

DO - 10.1046/j.1399-3038.2003.00129.x

M3 - Article

C2 - 15059185

SN - 0905-6157

VL - 15

SP - 103

EP - 111

JO - Pediatric Allergy and Immunology

JF - Pediatric Allergy and Immunology

IS - 2

ER -

Dietary prevention of allergic diseases in infants and small children. Part 1: Immunologic background and criteria for hypoallergenicity

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