Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity

D.J. Johns, A.K. Lindroos, S.A. Jebb, L.V. Sjöström, L.M.S. Carlsson, Gina Ambrosini

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Abstract

© 2014 The Obesity Society. Objective The longitudinal associations between a dietary pattern (DP) and cardiometabolic risk factors and cardiovascular disease (CVD) incidence were investigated in a cohort of adults with severe obesity. Methods The analysis included 2,037 individuals with severe obesity (>34 and >38 kg/m2 for men and women, respectively) from the Swedish Obese Subjects study repeatedly followed up for 10 years. Reduced rank regression was used to identify a DP characterized by dietary energy density, saturated fat intake, and fiber density. Mixed models examined relationships between repeated measures of DP z-scores and cardiometabolic risk factors. Cox proportional hazards models assessed relationships between DP scores and CVD incidence. Results An energy-dense, high-saturated-fat, and low-fiber DP was derived. A one-unit increase in the DP z-score between follow-ups was associated with an increase in weight [β (SE)] (1.71-±-0.10 kg), waist circumference (1.49-±-0.07 cm), BMI (0.60-±-0.34 kg/m2), serum cholesterol (0.06-±-0.01 mmol/l), and serum insulin (1.22-±-0.17 mmol/l; all P-
Original languageEnglish
Pages (from-to)1063-1070
JournalObesity
Volume23
Issue number5
DOIs
Publication statusPublished - 2015

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Johns, D. J., Lindroos, A. K., Jebb, S. A., Sjöström, L. V., Carlsson, L. M. S., & Ambrosini, G. (2015). Dietary patterns, cardiometabolic risk factors, and the incidence of cardiovascular disease in severe obesity. Obesity, 23(5), 1063-1070. https://doi.org/10.1002/oby.20920