Diagnostic utility of microsurgical carbon dioxide laser excision of oral potentially malignant lesions vs incisional biopsy: a retrospective histopathological review

Jacinta Vu, Hedley G. Coleman, Carsten E. Palme, Faruque Riffat, Mark Schifter, Hans Zoellner

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

Objective: Complete excision of oral potentially malignant lesions (OPMLs) could result in improved and earlier detection of more severe grades of oral epithelial dysplasia and/or frank malignancy. Transoral microsurgical carbon dioxide laser techniques allow for resection of OPMLs, even those that are extensive. The advantages are improved diagnostic yield, improved viability of the specimen for pathologic evaluation, reduced postoperative morbidity, and easier postoperative clinical surveillance. Study Design: Retrospective review of the histopathology slide material and attendant clinical notes of 31 sequential patients with OPMLs demonstrated the following histopathologic diagnoses on conventional incisional biopsy (CIB): verrucous hyperplasia (2 patients); mild dysplasia (11 patients), moderate dysplasia (3 patients) or severe dysplasia (15 patients); and subsequently, these patients went on to have laser excision biopsy (LEB) of their OPMLs. Results: Histologic diagnosis was upgraded after LEB in 14 (45%) patients (P < .001), with unexpected findings of cancer in 9 cases (29%) and more severe dysplasia in 5 cases (16%). Conclusions: Use of LEB to supplement CIB appears superior in the detection of severe dysplasia and frank malignancy in OPMLs compared with use of CIB alone. Prospective trials are indicated to determine if the superior diagnostic utility of LEB improves patient outcomes with regard to earlier detection of oral squamous cell and/or verrucous carcinoma.

Original languageEnglish
Pages (from-to)516-525
Number of pages10
JournalOral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Volume127
Issue number6
DOIs
Publication statusPublished - 1 Jun 2019

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Gas Lasers
Biopsy
Lasers
Verrucous Carcinoma
Neoplasms
Hyperplasia
Squamous Cell Carcinoma
Retrospective Studies
Morbidity

Cite this

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title = "Diagnostic utility of microsurgical carbon dioxide laser excision of oral potentially malignant lesions vs incisional biopsy: a retrospective histopathological review",
abstract = "Objective: Complete excision of oral potentially malignant lesions (OPMLs) could result in improved and earlier detection of more severe grades of oral epithelial dysplasia and/or frank malignancy. Transoral microsurgical carbon dioxide laser techniques allow for resection of OPMLs, even those that are extensive. The advantages are improved diagnostic yield, improved viability of the specimen for pathologic evaluation, reduced postoperative morbidity, and easier postoperative clinical surveillance. Study Design: Retrospective review of the histopathology slide material and attendant clinical notes of 31 sequential patients with OPMLs demonstrated the following histopathologic diagnoses on conventional incisional biopsy (CIB): verrucous hyperplasia (2 patients); mild dysplasia (11 patients), moderate dysplasia (3 patients) or severe dysplasia (15 patients); and subsequently, these patients went on to have laser excision biopsy (LEB) of their OPMLs. Results: Histologic diagnosis was upgraded after LEB in 14 (45{\%}) patients (P < .001), with unexpected findings of cancer in 9 cases (29{\%}) and more severe dysplasia in 5 cases (16{\%}). Conclusions: Use of LEB to supplement CIB appears superior in the detection of severe dysplasia and frank malignancy in OPMLs compared with use of CIB alone. Prospective trials are indicated to determine if the superior diagnostic utility of LEB improves patient outcomes with regard to earlier detection of oral squamous cell and/or verrucous carcinoma.",
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Diagnostic utility of microsurgical carbon dioxide laser excision of oral potentially malignant lesions vs incisional biopsy : a retrospective histopathological review. / Vu, Jacinta; Coleman, Hedley G.; Palme, Carsten E.; Riffat, Faruque; Schifter, Mark; Zoellner, Hans.

In: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology, Vol. 127, No. 6, 01.06.2019, p. 516-525.

Research output: Contribution to journalArticle

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AU - Schifter, Mark

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