Diagnosis and Management of Immunological Diseases requires Sirtuin 1 as a Diagnostic protein marker

Ian Martins

Research output: Contribution to conferenceAbstractpeer-review


Laboratory evaluations using established and emerging techniques in immunology are essential for the diagnosis and management of immune-mediated disorders. Inter-relationship between immunology and other laboratories such as chemistry, microbiology, and hematology now may overlap in diagnostic tests. Diagnosis of allergy, autoimmune disease serology, protein immunology including complement testing, cancer immunology, histocompatibility and immunogenetics, primary/secondary immunodeficiencies and infectious disease serology may now require analysis of a diagnositc protein that is critical for interpretation of global health and chronic disease. Sirtuin 1 analysis on blood, plasma and sera may be important to immunological tests with collection of plasma/sera sensitive to the appropriate preservative, freeze/thaw conditions and long term storage conditions. Bacterial lipopolysaccharides need to assayed on samples to avoid misinterpretations with relevance to Sirtuin 1 repression in immunological diseases. RELEVANT REFERENCSES 1. Anne E. Tebo, Barbara Detrick, Robert G. Hamilton, Aaruni Khanolkar, Maurice R. G. O’Gorman, John L. Schmitz, Roshini S. Abraham; Clinical Laboratory Immunology: An Indispensable Player in Laboratory Medicine, American Journal of Clinical Pathology, Volume 142, Issue 4, 1 October 2014, Pages 437–444, https://doi.org/10.1309/AJCPX25MFWNEYRIG 2. ONLINE: Sirtuin 1, a Diagnostic Protein Marker and its Relevance to Chronic Disease and Therapeutic Drug Interventions”. EC Pharmacology and Toxicology, 2018 CERTIFICATE OF PUBLICATION. 3. ONLINE: Evaluation of diagnostic tests in human health and disease. J Clin Path Lab Med. 2018. 4. The Future of Biomarkers Tests and Genomic Medicine in Global Organ Disease. Arch Infect Dis Ther. 2017. 5. The Future of Genomic Medicine Involves the Maintenance of Sirtuin 1 in Global Populations. Int J Mol Biol. 2017. 6. Biomarker Tests and Ageing Science. Ageing Sci Ment Health Stud. 2017. 7. The Limitations of Food Intake and Biomarkers in the Prevention of Chronic Diseases. Nov Tech Nutri Food Sci. 2017. 8. Bacterial Lipopolysaccharides Change Membrane Fluidity with Relevance to Phospholipid and Amyloid Beta Dynamics in Alzheimer’s Disease. J Microb Biochem Technol. 2016. 9. The Role of Clinical Proteomics, Lipidomics, and Genomics in the Diagnosis of Alzheimer’s Disease. Proteomes, 2016. 10. LPS Regulates Apolipoprotein E and Aβ Interactions with Effects on Acute Phase Proteins and Amyloidosis. Advances in Aging Research 2015.
Original languageEnglish
Publication statusPublished - 19 Apr 2018
Event7th World Congress on Immunology - Amsterdam, Netherlands
Duration: 19 Apr 201920 Apr 2019


Conference7th World Congress on Immunology


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