Diabetes and cholesterol dyshomeostasis involve abnormal α-synuclein and amyloid beta transport in neurodegenerative diseases

Research output: Contribution to conferenceAbstract

Abstract

The understanding of molecular mechanisms underlying diet and Alzheimer’s disease and the cholesterol connection are important for prevention and treatment of Alzheimer’s disease linked to Type 3 diabetes and aberrant lipid metabolism. Cholesterol modulates amyloid beta generation with the ATP-binding cassette transporter 1 as a major regulator of cholesterol and phospholipids from cell membranes involved in amyloid beta transport from the brain to the liver for metabolism. In Parkinson’s disease the α-synuclein protein binds to cholesterol (tilted peptide 67-78/isooctyl chain) in cell membranes. Fatty acids, cholesterol and phospholipids such as phosphatidylinositol in membranes are sensitive to amyloid beta and α-synuclein binding/aggregation indicate the involvement of lipids in the progression of AD and PD. The global obesity and Type 2 diabetes epidemic indicate that down regulation of Sirtuin 1 is associated with increased plasma α-synuclein levels in the modulation of membrane ion channels, impairments in protein degradation with abnormal endoplasmic reticulum-mitochondrial interactions associated with disturbed peripheral amyloid beta metabolism common to both Parkinson’s disease and Alzheimer’s disease
Original languageEnglish
Publication statusPublished - 13 Nov 2015
EventBit's 6th World Gene Convention-2015 - Qingdao, China
Duration: 13 Nov 201515 Nov 2015

Conference

ConferenceBit's 6th World Gene Convention-2015
CountryChina
CityQingdao
Period13/11/1515/11/15

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