Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum HELLP syndrome

D.M. Isler; Pat Magann; B.K. Rinehard; D.A. Terrone; J.D. Bass; J.N. Martin

doi:10.1016/S0020-7292(02)00394-6

Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum HELLP syndrome

D.M. Isler, Pat Magann, B.K. Rinehard, D.A. Terrone, J.D. Bass, J.N. Martin

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Abstract

Objectives: To compare the efficacy of dexamethasone and betamethasone to ameliorate the course of postpartum hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. Methods: A prospective, mixed randomized/non-randomized clinical investigation of patients with postpartum HELLP syndrome. Treatment with either dexamethasone or betamethasone was continued until there was evidence of disease recovery. Results: Baseline characteristics of both the dexamethasone (n=18) and betamethasone (n=18) groups were similar. Although the time to discharge from the obstetrical recovery room was not statistically significant between groups, reduction in mean arterial blood pressure was more pronounced in the dexamethasone group as compared with the betamethasone group (−15.3±1.4 mmHg vs. −7.5±1.4 mmHg, respectively, P

Original language	English
Pages (from-to)	291-297
Journal	International Journal of Gynecology Obstetrics
Volume	80
Issue number	3
DOIs	https://doi.org/10.1016/S0020-7292(02)00394-6
Publication status	Published - 2003

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abstract = "Objectives: To compare the efficacy of dexamethasone and betamethasone to ameliorate the course of postpartum hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. Methods: A prospective, mixed randomized/non-randomized clinical investigation of patients with postpartum HELLP syndrome. Treatment with either dexamethasone or betamethasone was continued until there was evidence of disease recovery. Results: Baseline characteristics of both the dexamethasone (n=18) and betamethasone (n=18) groups were similar. Although the time to discharge from the obstetrical recovery room was not statistically significant between groups, reduction in mean arterial blood pressure was more pronounced in the dexamethasone group as compared with the betamethasone group (−15.3±1.4 mmHg vs. −7.5±1.4 mmHg, respectively, P",

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T1 - Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum HELLP syndrome

AU - Isler, D.M.

AU - Magann, Pat

AU - Rinehard, B.K.

AU - Terrone, D.A.

AU - Bass, J.D.

AU - Martin, J.N.

PY - 2003

Y1 - 2003

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AB - Objectives: To compare the efficacy of dexamethasone and betamethasone to ameliorate the course of postpartum hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. Methods: A prospective, mixed randomized/non-randomized clinical investigation of patients with postpartum HELLP syndrome. Treatment with either dexamethasone or betamethasone was continued until there was evidence of disease recovery. Results: Baseline characteristics of both the dexamethasone (n=18) and betamethasone (n=18) groups were similar. Although the time to discharge from the obstetrical recovery room was not statistically significant between groups, reduction in mean arterial blood pressure was more pronounced in the dexamethasone group as compared with the betamethasone group (−15.3±1.4 mmHg vs. −7.5±1.4 mmHg, respectively, P

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DO - 10.1016/S0020-7292(02)00394-6

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EP - 297

JO - International Journal of Gynecology Obstetrics

JF - International Journal of Gynecology Obstetrics

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