Dexamethasone compared with betamethasone for glucocorticoid treatment of postpartum HELLP syndrome

D.M. Isler, Pat Magann, B.K. Rinehard, D.A. Terrone, J.D. Bass, J.N. Martin

    Research output: Contribution to journalArticle

    36 Citations (Scopus)

    Abstract

    Objectives: To compare the efficacy of dexamethasone and betamethasone to ameliorate the course of postpartum hemolysis, elevated liver enzymes, low platelets (HELLP) syndrome. Methods: A prospective, mixed randomized/non-randomized clinical investigation of patients with postpartum HELLP syndrome. Treatment with either dexamethasone or betamethasone was continued until there was evidence of disease recovery. Results: Baseline characteristics of both the dexamethasone (n=18) and betamethasone (n=18) groups were similar. Although the time to discharge from the obstetrical recovery room was not statistically significant between groups, reduction in mean arterial blood pressure was more pronounced in the dexamethasone group as compared with the betamethasone group (−15.3±1.4 mmHg vs. −7.5±1.4 mmHg, respectively, P
    Original languageEnglish
    Pages (from-to)291-297
    JournalInternational Journal of Gynecology Obstetrics
    Volume80
    Issue number3
    DOIs
    Publication statusPublished - 2003

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