Developmental vitamin D deficiency produces behavioral phenotypes of relevance to Autism in an animal model

Asad Ali, Svetlina Vasileva, Mia Langguth, Suzanne Alexander, Xiaoying Cui, Andrew Whitehouse, John J. McGrath, Darryl Eyles

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Emerging evidence suggests that gestational or developmental vitamin D (DVD) deficiency is associated with an increased risk of autism spectrum disorder (ASD). ASD is a neurodevelopmental disorder characterized by impairments in social interaction, lack of verbal and non-verbal communications, stereotyped repetitive behaviors and hyper-activities. There are several other clinical features that are commonly comorbid with ASD, including olfactory impairments, anxiety and delays in motor development. Here we investigate these features in an animal model related to ASD—the DVD-deficient rat. Compared to controls, both DVD-deficient male and female pups show altered ultrasonic vocalizations and stereotyped repetitive behavior. Further, the DVD-deficient animals had delayed motor development and impaired motor control. Adolescent DVD-deficient animals had impaired reciprocal social interaction, while as adults, these animals were hyperactive. The DVD-deficient model is associated with a range of behavioral features of interest to ASD.

Original languageEnglish
Article number1187
JournalNutrients
Volume11
Issue number5
DOIs
Publication statusPublished - 1 May 2019

Fingerprint Dive into the research topics of 'Developmental vitamin D deficiency produces behavioral phenotypes of relevance to Autism in an animal model'. Together they form a unique fingerprint.

  • Cite this