Developmental changes in the glucocorticoid induction of hepatic tyrosine aminotransferase

M. H. Cake, G. Yeoh, I. T. Oliver, G. Litwack

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

The administration of glucocorticoids fails to induce tyrosine aminotransferase activity in fetal rat liver in utero but causes a marked increase in the activity of this enzyme in postnatal rats. In adult animals, this increase has been shown to be the result of the production of enhanced amounts of mRNA for tyrosine aminotransferase, leading to an increase in the rate of synthesis of the enzyme. The lack of steroid response in utero is not due to an impairment in uptake of the hormone by fetal liver, nor is it due to a lack of glucocorticoid receptors, as both cytoplasmic and nuclear receptors have been detected in fetal liver. In studies with cultured fetal hepatocytes, dexamethasone is able to induce the enzyme but the presence of insulin prevents this induction at a post-transcriptional step. It is therefore proposed, that glucocorticoids are active at the transcriptional level in fetal liver but that a high concentration of insulin inhibits some post-transcriptional process, thus preventing the synthesis of tyrosine aminotransferase (TAT).

Original languageEnglish
Pages (from-to)263-272
Number of pages10
JournalAdvances in the Biosciences
Volume25
Issue numberC
Publication statusPublished - 1 Dec 1980
Externally publishedYes

Fingerprint

Tyrosine Transaminase
Glucocorticoids
Liver
Enzymes
Insulin
Fetal Movement
Glucocorticoid Receptors
Cytoplasmic and Nuclear Receptors
Dexamethasone
Hepatocytes
Steroids
Hormones
Messenger RNA

Cite this

Cake, M. H. ; Yeoh, G. ; Oliver, I. T. ; Litwack, G. / Developmental changes in the glucocorticoid induction of hepatic tyrosine aminotransferase. In: Advances in the Biosciences. 1980 ; Vol. 25, No. C. pp. 263-272.
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Developmental changes in the glucocorticoid induction of hepatic tyrosine aminotransferase. / Cake, M. H.; Yeoh, G.; Oliver, I. T.; Litwack, G.

In: Advances in the Biosciences, Vol. 25, No. C, 01.12.1980, p. 263-272.

Research output: Contribution to journalArticle

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