Developmental and morphological studies in Japanese medaka with ultra-high resolution optical coherence tomography

Fanny Moses Gladys, Masaru Matsuda, Yiheng Lim, Boaz Jessie Jackin, Takuto Imai, Yukitoshi Otani, Toyohiko Yatagai, Barry Cense

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3 Citations (Scopus)


We propose ultra-high resolution optical coherence tomography to study the morphological development of internal organs in medaka fish in the post-embryonic stages at micrometer resolution. Different stages of Japanese medaka were imaged after hatching in vivo with an axial resolution of 2.8 mu m in tissue. Various morphological structures and organs identified in the OCT images were then compared with the histology. Due to the medaka's close resemblance to vertebrates, including humans, these morphological features play an important role in morphogenesis and can be used to study diseases that also occur in humans. (C)2015 Optical Society of America

Original languageEnglish
Pages (from-to)297-308
Number of pages12
JournalBiomedical Optics Express
Issue number2
Publication statusPublished - 1 Feb 2015
Externally publishedYes

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