Development of [66Ga]oxine complex; a possible PET tracer

Amir R. Jalilian; Pejman Rowshanfarzad; Mahsheed Sabet; Ali Rahiminejad-Kisomi; Amir A. Rajamand

Development of [⁶⁶Ga]oxine complex; a possible PET tracer

Amir R. Jalilian, Pejman Rowshanfarzad, Mahsheed Sabet, Ali Rahiminejad-Kisomi, Amir A. Rajamand

School of Physics, Mathematics and Computing

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T_1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [ ⁶⁶Ga]gallium chloride for its possible diagnostic properties. In this study, ⁶⁶Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the ⁶⁶Zn(p,n)⁶⁶Ga reaction. The production yield was 445.5 MBq/μAh. The [⁶⁶Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 ± 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [⁶⁶Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.

Original language	English
Pages (from-to)	155-159
Number of pages	5
Journal	Nukleonika
Volume	51
Issue number	3
Publication status	Published - 28 Sept 2006

Cite this

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title = "Development of [66Ga]oxine complex; a possible PET tracer",

abstract = "The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [ 66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/μAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 ± 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.",

keywords = "Blood cell labeling, Gallium-66, Oxine, Positron emission tomography, Stability",

author = "Jalilian, {Amir R.} and Pejman Rowshanfarzad and Mahsheed Sabet and Ali Rahiminejad-Kisomi and Rajamand, {Amir A.}",

year = "2006",

month = sep,

day = "28",

language = "English",

volume = "51",

pages = "155--159",

journal = "Nukleonika",

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TY - JOUR

T1 - Development of [66Ga]oxine complex; a possible PET tracer

AU - Jalilian, Amir R.

AU - Rowshanfarzad, Pejman

AU - Sabet, Mahsheed

AU - Rahiminejad-Kisomi, Ali

AU - Rajamand, Amir A.

PY - 2006/9/28

Y1 - 2006/9/28

N2 - The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [ 66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/μAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 ± 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.

AB - The aim of this work is development of a possible blood cell labeling agent for ultimate use in PET. Gallium-66 (T1/2 = 9.49 h) is an interesting radionuclide that has a potential for positron emission tomography (PET) imaging of biological processes with intermediate to slow target tissue uptake. Oxine has been labeled with this radionuclide in the form of [ 66Ga]gallium chloride for its possible diagnostic properties. In this study, 66Ga was produced at a 30 MeV cyclotron (IBA-Cyclone 30) via the 66Zn(p,n)66Ga reaction. The production yield was 445.5 MBq/μAh. The [66Ga]oxine complex was obtained at pH = 5 in phosphate buffer medium at 37°C in 10 min. Radio-TLC showed a radiochemical purity of more than 98 ± 2%. The chemical stability of the complex was checked in vitro with a specific activity of 1113 GBq/mmol. The serum stability and log P of the complex were calculated. The produced [66Ga]oxine can be used for diagnostic studies, due to its desirable physico-chemical properties both in vitro and in vivo according to internationally accepted limits.

KW - Blood cell labeling

KW - Gallium-66

KW - Oxine

KW - Positron emission tomography

KW - Stability

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M3 - Article

AN - SCOPUS:33748945378

SN - 0029-5922

VL - 51

SP - 155

EP - 159

JO - Nukleonika

JF - Nukleonika

IS - 3

ER -

Development of [⁶⁶Ga]oxine complex; a possible PET tracer

Abstract

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