Development of semiquantitative ultrasound scoring system to assess cartilage in rheumatoid arthritis

Peter Mandl, Paul Studenic, Emilio Filippucci, Artur Bachta, Marina Backhaus, David Bong, George A.W. Bruyn, Paz Collado, Nemanja Damjanov, Christian Dejaco, Andrea Delle-Sedie, Eugenio De Miguel, Christina Duftner, Irina Gessl, Marwin Gutierrez, Hilde B. Hammer, Cristina Hernandez-Diaz, Annmaria Iagnocco, Kei Ikeda, David KaneHelen Keen, Stephen Kelly, Eszter Kovári, Ingrid Möller, Uffe Møller-Dohn, Esperanza Naredo, Juan C. Nieto, Carlos Pineda, Alex Platzer, Ana Rodriguez, Wolfgang A. Schmidt, Gabriela Supp, Marcin Szkudlarek, Lene Terslev, Ralf Thiele, Richard J. Wakefield, Daniel Windschall, Maria Antonietta D'Agostino, Peter V. Balint

Research output: Contribution to journalArticlepeer-review

18 Citations (Scopus)


To develop and test the reliability of a new semiquantitative scoring system for the assessment of cartilage changes by ultrasound in a web-based exercise as well as a patient exercise of patients with RA. Methods: A taskforce of the Outcome Measures in Rheumatology Ultrasound Working Group performed a systematic literature review on the US assessment of cartilage in RA, followed by a Delphi survey on cartilage changes and a new semiquantitative US scoring system, and finally a web-based exercise as well as a patient exercise. For the web-based exercise, taskforce members scored a dataset of anonymized static images of MCP joints in RA patients and healthy controls, which also contained duplicate images. Subsequently, 12 taskforce members used the same US to score cartilage in MCP and proximal interphalangeal joints of six patients with RA in in a patient reliability exercise. Percentage agreement and prevalence of lesions were calculated, as intrareader reliability was assessed by weighted kappa and interreader reliability by Light's kappa. Results: The three-grade semiquantitative scoring system demonstrated excellent intrareader reliability (kappa: 0.87 and 0.83) in the web-based exercise and the patient exercise, respectively. Interreader reliability was good in the web-based exercise (kappa: 0.64) and moderate (kappa: 0.48) in the patient exercise. Conclusion: Our study demonstrates that ultrasound is a reliable tool for evaluating cartilage changes in the MCP joints of patients with RA and supports further development of a new reliable semiquantitative ultrasound scoring system for evaluating cartilage involvement in RA.

Original languageEnglish
Pages (from-to)1802-1811
Number of pages10
JournalRheumatology (United Kingdom)
Issue number10
Publication statusPublished - 1 Oct 2019


Dive into the research topics of 'Development of semiquantitative ultrasound scoring system to assess cartilage in rheumatoid arthritis'. Together they form a unique fingerprint.

Cite this