Development of optical coherence elastography towards precise and accurate mechanical characterisation of cells and tissues

Jiayue Li

doi:10.26182/3g4e-7984

Development of optical coherence elastography towards precise and accurate mechanical characterisation of cells and tissues

Jiayue Li

School of Engineering

Research output: Thesis › Doctoral Thesis

14 Downloads (Pure)

Abstract

Optical coherence elastography (OCE) holds promise to image mechanical properties on the microscale with millimetre-scale penetration depth. Whilst OCE has been demonstrated in many applications, most notably in ophthalmology and oncology, there remains a great deal of work to develop OCE towards a precise and accurate mechanical characterisation technique for broad application in biomedicine. This Thesis features a number of advances in the development of OCE towards precise and accurate mechanical characterisation of cells and tissues, which may contribute to discoveries in mechanobiology and tissue mechanics.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Supervisors/Advisors	Mowla, Alireza, Supervisor Zheng, Minghao, Supervisor Kennedy, Brendan, Supervisor
Award date	4 Sept 2023
DOIs	https://doi.org/10.26182/3g4e-7984
Publication status	Unpublished - 2023

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10.26182/3g4e-7984

THESIS - DOCTOR OF PHILOSOPHY - LI Jiayue - 2023
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5 Article

Tension-Based Optical Coherence Elastography: Mapping the Micro-Scale Strain Tensor Resulting From Tensile Loading
Li, J., Mowla, A., Chen, Z., Hepburn, M. S., Chin, L., Zheng, M. & Kennedy, B. F., 1 Jul 2023, In: IEEE Journal of Selected Topics in Quantum Electronics. 29, 4, 6800514.
Research output: Contribution to journal › Article › peer-review
Subcellular mechano-microscopy: high resolution three-dimensional elasticity mapping using optical coherence microscopy
Mowla, A., Li, J., Hepburn, M. S., Maher, S., Chin, L., Yeoh, G. C., Choi, Y. S. & Kennedy, B. F., 1 Jul 2022, In: Optics Letters. 47, 13, p. 3303-3306 4 p.
Research output: Contribution to journal › Article › peer-review
5 Citations (Scopus)
Three-dimensional mechanical characterization of murine skeletal muscle using quantitative micro-elastography
Lloyd, E. M., Hepburn, M. S., Li, J., Mowla, A., Hwang, Y., Choi, Y. S., Grounds, M. D. & Kennedy, B. F., Nov 2022, In: Biomedical Optics Express. 13, 11, p. 5879-5899 21 p., 5879.
Research output: Contribution to journal › Article › peer-review

Open Access
1 Citation (Scopus)

Cite this

@phdthesis{2dfdfd7e1dae46418a1ff8bdf9e98b50,

title = "Development of optical coherence elastography towards precise and accurate mechanical characterisation of cells and tissues",

abstract = "Optical coherence elastography (OCE) holds promise to image mechanical properties on the microscale with millimetre-scale penetration depth. Whilst OCE has been demonstrated in many applications, most notably in ophthalmology and oncology, there remains a great deal of work to develop OCE towards a precise and accurate mechanical characterisation technique for broad application in biomedicine. This Thesis features a number of advances in the development of OCE towards precise and accurate mechanical characterisation of cells and tissues, which may contribute to discoveries in mechanobiology and tissue mechanics.",

keywords = "Biomedical Optics, Optical coherence elastography, Mechanical characterisation, Biomechanics",

author = "Jiayue Li",

year = "2023",

doi = "10.26182/3g4e-7984",

language = "English",

school = "The University of Western Australia",

}

TY - THES

T1 - Development of optical coherence elastography towards precise and accurate mechanical characterisation of cells and tissues

AU - Li, Jiayue

PY - 2023

Y1 - 2023

N2 - Optical coherence elastography (OCE) holds promise to image mechanical properties on the microscale with millimetre-scale penetration depth. Whilst OCE has been demonstrated in many applications, most notably in ophthalmology and oncology, there remains a great deal of work to develop OCE towards a precise and accurate mechanical characterisation technique for broad application in biomedicine. This Thesis features a number of advances in the development of OCE towards precise and accurate mechanical characterisation of cells and tissues, which may contribute to discoveries in mechanobiology and tissue mechanics.

AB - Optical coherence elastography (OCE) holds promise to image mechanical properties on the microscale with millimetre-scale penetration depth. Whilst OCE has been demonstrated in many applications, most notably in ophthalmology and oncology, there remains a great deal of work to develop OCE towards a precise and accurate mechanical characterisation technique for broad application in biomedicine. This Thesis features a number of advances in the development of OCE towards precise and accurate mechanical characterisation of cells and tissues, which may contribute to discoveries in mechanobiology and tissue mechanics.

KW - Biomedical Optics

KW - Optical coherence elastography

KW - Mechanical characterisation

KW - Biomechanics

U2 - 10.26182/3g4e-7984

DO - 10.26182/3g4e-7984

M3 - Doctoral Thesis

ER -

Development of optical coherence elastography towards precise and accurate mechanical characterisation of cells and tissues

Abstract

Access to Document

Research output

Tension-Based Optical Coherence Elastography: Mapping the Micro-Scale Strain Tensor Resulting From Tensile Loading

Subcellular mechano-microscopy: high resolution three-dimensional elasticity mapping using optical coherence microscopy

Three-dimensional mechanical characterization of murine skeletal muscle using quantitative micro-elastography

Cite this