Development of immuno-flowFISH by imaging flow cytometry for the analysis of haematoligical maligancies

Henry Hui

doi:10.26182/5cf73431ee261

Development of immuno-flowFISH by imaging flow cytometry for the analysis of haematoligical maligancies

Henry Hui

Research output: Thesis › Doctoral Thesis

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Abstract

The outcome of my PhD is the development of a new invention for studying leukaemia. The method, called immuno-flowFISH, enables many thousand cells to be analysed to detect abnormal chromosomes. This invention is a world-first: it is automated, is more precise as only leukaemia cells are analysed and is 1,000-times more sensitive than established tests. Once I established the test, I evaluated its performance on chronic lymphocytic leukaemia, the commonest leukaemia in the western world. This confirmed its capability as a diagnostic test. The invention has been patented and won the ANSTO 2018 Eureka Prize for Innovative use of Technology.

Original language	English
Qualification	Doctor of Philosophy
Awarding Institution	The University of Western Australia
Thesis sponsors	Australian Government Research Training Program
Award date	30 Apr 2019
DOIs	https://doi.org/10.26182/5cf73431ee261
Publication status	Unpublished - 2018

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10.26182/5cf73431ee261

THESIS - DOCTOR OF PHILOSOPHY - HUI Menry Yeuk - 2018
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Cite this

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title = "Development of immuno-flowFISH by imaging flow cytometry for the analysis of haematoligical maligancies",

abstract = "The outcome of my PhD is the development of a new invention for studying leukaemia. The method, called immuno-flowFISH, enables many thousand cells to be analysed to detect abnormal chromosomes. This invention is a world-first: it is automated, is more precise as only leukaemia cells are analysed and is 1,000-times more sensitive than established tests. Once I established the test, I evaluated its performance on chronic lymphocytic leukaemia, the commonest leukaemia in the western world. This confirmed its capability as a diagnostic test. The invention has been patented and won the ANSTO 2018 Eureka Prize for Innovative use of Technology.",

keywords = "Imaging flow cytometry, Immunophenotype, MRD monitoring, Immuno-flowFISH, Cancer diagnosis, Invention and automation, Diagnostic test, Blood test, Leukaemia, chronic lymphocytic leukaemia, Fluorescence in situ hybridization, haematological malignancy",

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school = "The University of Western Australia",

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N2 - The outcome of my PhD is the development of a new invention for studying leukaemia. The method, called immuno-flowFISH, enables many thousand cells to be analysed to detect abnormal chromosomes. This invention is a world-first: it is automated, is more precise as only leukaemia cells are analysed and is 1,000-times more sensitive than established tests. Once I established the test, I evaluated its performance on chronic lymphocytic leukaemia, the commonest leukaemia in the western world. This confirmed its capability as a diagnostic test. The invention has been patented and won the ANSTO 2018 Eureka Prize for Innovative use of Technology.

AB - The outcome of my PhD is the development of a new invention for studying leukaemia. The method, called immuno-flowFISH, enables many thousand cells to be analysed to detect abnormal chromosomes. This invention is a world-first: it is automated, is more precise as only leukaemia cells are analysed and is 1,000-times more sensitive than established tests. Once I established the test, I evaluated its performance on chronic lymphocytic leukaemia, the commonest leukaemia in the western world. This confirmed its capability as a diagnostic test. The invention has been patented and won the ANSTO 2018 Eureka Prize for Innovative use of Technology.

KW - Imaging flow cytometry

KW - Immunophenotype

KW - MRD monitoring

KW - Immuno-flowFISH

KW - Cancer diagnosis

KW - Invention and automation

KW - Diagnostic test

KW - Blood test

KW - Leukaemia

KW - chronic lymphocytic leukaemia

KW - Fluorescence in situ hybridization

KW - haematological malignancy

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DO - 10.26182/5cf73431ee261

M3 - Doctoral Thesis

ER -

Development of immuno-flowFISH by imaging flow cytometry for the analysis of haematoligical maligancies

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