TY - JOUR
T1 - Development of a reliable and reproducible phantom manufacturing method using silica microspheres in silicone
AU - Maughan Jones, Charlotte J.
AU - Munro, Peter R.T.
PY - 2017/9/1
Y1 - 2017/9/1
N2 - Optically scattering phantoms composed of silica microspheres embedded in an optically clear silicone matrix were manufactured using a previously developed method. Multiple problems, such as sphere aggregation, adsorption to the cast, and silicone shrinkage, were, however, frequently encountered. Solutions to these problems were developed and an improved method, incorporating these solutions, is presented. The improved method offers excellent reliability and reproducibility for creating phantoms with uniform scattering coefficient. We also present evidence of decreased sphere aggregation.
AB - Optically scattering phantoms composed of silica microspheres embedded in an optically clear silicone matrix were manufactured using a previously developed method. Multiple problems, such as sphere aggregation, adsorption to the cast, and silicone shrinkage, were, however, frequently encountered. Solutions to these problems were developed and an improved method, incorporating these solutions, is presented. The improved method offers excellent reliability and reproducibility for creating phantoms with uniform scattering coefficient. We also present evidence of decreased sphere aggregation.
KW - Mie theory
KW - Optical scattering
KW - Phantoms
KW - Spectrophotometry
UR - http://www.scopus.com/inward/record.url?scp=85029838334&partnerID=8YFLogxK
U2 - 10.1117/1.JBO.22.9.095004
DO - 10.1117/1.JBO.22.9.095004
M3 - Article
C2 - 28925108
AN - SCOPUS:85029838334
SN - 1083-3668
VL - 22
JO - Journal of Biomedical Optics
JF - Journal of Biomedical Optics
IS - 9
M1 - 095004
ER -